A clinical trial of University of Wisconsin solution for pulmonary preservation

R. L. Hardesty, R. Aeba, J. M. Armitage, R. L. Kormos, B. P. Griffith

Research output: Contribution to journalArticle

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Abstract

Suboptimal pulmonary preservation with modified Euro-Collins solution (9/90 to 4/91) prompted us to change to University of Wisconsin solution (4/91 to 4/92). Between September 1990 and April 1992, 94 patients received 100 pulmonary allografts (13 heart-lungs, 45 double lungs, 42 single lungs) that were flushed and preserved with either Euro-Collins (n = 30) or University of Wisconsin (n = 70) solution. Selection of donors and procurement and storage of donor lungs were identical. Bilateral single lung transplantation was performed more often in the University of Wisconsin group and resulted in a significantly longer graft ischemic time (University of Wisconsin group; 303 ± 62 minutes; Euro-Collins group; 260 ± 62 minutes; p = 0.007, t test). The use of cardiopulmonary bypass was not statistically significantly different. Preservation injury identified by the radiograph on day 1 was more severe (p = 0.036; Mann-Whitney U test) in the Euro-Collins group than in the University of Wisconsin group. In double lung and heart- lung recipients gas exchange of the allografts was evaluated by the arterial/alveolar oxygen tension ratios at nine intervals during the first 72 hours. The mean arterial/alveolar oxygen tension ratio was 0.62 ± 0.26 in the University of Wisconsin group and 0.46 ± 0.23 in the Euro-Collins group, but this difference did not reach significance (p = 0.119, analysis of variance). Despite the longer ischemic time, pulmonary preservation achieved by University of Wisconsin solution appears to be comparable with that achieved by Euro-Collins solution.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume105
Issue number4
Publication statusPublished - 1993
Externally publishedYes

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Clinical Trials
Lung
Allografts
Oxygen
Donor Selection
Lung Transplantation
Nonparametric Statistics
Cardiopulmonary Bypass
Analysis of Variance
Gases
Tissue Donors
Transplants
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Hardesty, R. L., Aeba, R., Armitage, J. M., Kormos, R. L., & Griffith, B. P. (1993). A clinical trial of University of Wisconsin solution for pulmonary preservation. Journal of Thoracic and Cardiovascular Surgery, 105(4), 660-666.

A clinical trial of University of Wisconsin solution for pulmonary preservation. / Hardesty, R. L.; Aeba, R.; Armitage, J. M.; Kormos, R. L.; Griffith, B. P.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 105, No. 4, 1993, p. 660-666.

Research output: Contribution to journalArticle

Hardesty, RL, Aeba, R, Armitage, JM, Kormos, RL & Griffith, BP 1993, 'A clinical trial of University of Wisconsin solution for pulmonary preservation', Journal of Thoracic and Cardiovascular Surgery, vol. 105, no. 4, pp. 660-666.
Hardesty, R. L. ; Aeba, R. ; Armitage, J. M. ; Kormos, R. L. ; Griffith, B. P. / A clinical trial of University of Wisconsin solution for pulmonary preservation. In: Journal of Thoracic and Cardiovascular Surgery. 1993 ; Vol. 105, No. 4. pp. 660-666.
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