A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects

Anna Kaisa Niemi, Jukka S. Moilanen, Masashi Tanaka, Antti Hervonen, Mikko Hurme, Terho Lehtimäki, Yasumichi Arai, Nobuyoshi Hirose, Kari Majamaa

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Abstract

Mitochondrial DNA (mtDNA) coding region polymorphisms, as well as the 150T polymorphism in the noncoding region, have been associated with longevity. We have studied here the association of 150T with longevity further and assessed differences in this association between various mtDNA haplogroups. We analysed a sample of 321 very old subjects and 489 middle-aged controls from Finland and Japan. 150T was more frequent among the very old than among the controls in both the Finnish and Japanese subjects. Interestingly, the association was not similar in all haplogroups, and a stratified analysis revealed that two additional common polymorphisms, 489C and 10398G, modified the association between 150T and longevity. These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalEuropean Journal of Human Genetics
Volume13
Issue number2
DOIs
Publication statusPublished - 2005 Feb 1

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Keywords

  • Association study
  • Control region
  • Epistasis
  • Haplogroup
  • Longevity
  • Mitochondrial DNA
  • Phylogenetic analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Niemi, A. K., Moilanen, J. S., Tanaka, M., Hervonen, A., Hurme, M., Lehtimäki, T., Arai, Y., Hirose, N., & Majamaa, K. (2005). A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. European Journal of Human Genetics, 13(2), 166-170. https://doi.org/10.1038/sj.ejhg.5201308