A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling

Narutaka Ohashi, Hideo Mitamura, Kojiro Tanimoto, Yukiko Fukuda, Osamu Kinebuchi, Yasuo Kurita, Akiko Shiroshita-Takeshita, Shunichiro Miyoshi, Motoki Hara, Seiji Takatsuki, Satoshi Ogawa

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44 Citations (Scopus)

Abstract

Calcium overload plays a key role in the development of atrial electrical remodeling. The effect of an L-type Ca channel blocker in preventing this remodeling has been reported to be short lasting, partly due to down-regulation of this channel and persisting Ca entry through the T-type Ca channel. To prove if efonidipine, a dual L- and T-type Ca channel blocker exerts a greater effect than an L-type Ca channel blocker verapamil, 21 dogs underwent rapid atrial pacing at 400 bpm for 14 days, pretreatment with efonidipine in 7 (E), verapamil in 7 (V), and none in 7 (C). We measured the atrial effective refractory period (ERP) serially during 14 days of rapid pacing. In response to rapid pacing, ERP decreased progressively in C. In contrast, in E and V, ERP remained greater than ERP in C (P < 0.01) on days 2 through 7. However, on the 14th day, ERP in V decreased to the level seen in C, whereas ERP in E remained significantly longer than ERPs in C or V (P < 0.01). The blockade L-type Ca channel alone is not sufficient, but the addition of a T-type Ca channel blockade shows a more sustained effect to prevent atrial electrical remodeling.

Original languageEnglish
Pages (from-to)386-392
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume44
Issue number3
DOIs
Publication statusPublished - 2004 Sep 1

Keywords

  • Arrhythmia (mechanism)
  • Atrium
  • Ca channel blocker
  • Electrophysiology
  • T-type Ca channel

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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    Ohashi, N., Mitamura, H., Tanimoto, K., Fukuda, Y., Kinebuchi, O., Kurita, Y., Shiroshita-Takeshita, A., Miyoshi, S., Hara, M., Takatsuki, S., & Ogawa, S. (2004). A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. Journal of Cardiovascular Pharmacology, 44(3), 386-392. https://doi.org/10.1097/01.fjc.0000138163.11612.7b