A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling

Narutaka Ohashi, Hideo Mitamura, Kojiro Tanimoto, Yukiko Fukuda, Osamu Kinebuchi, Yasuo Kurita, Akiko Shiroshita-Takeshita, Shunichiro Miyoshi, Motoki Hara, Seiji Takatsuki, Satoshi Ogawa

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Calcium overload plays a key role in the development of atrial electrical remodeling. The effect of an L-type Ca channel blocker in preventing this remodeling has been reported to be short lasting, partly due to down-regulation of this channel and persisting Ca entry through the T-type Ca channel. To prove if efonidipine, a dual L- and T-type Ca channel blocker exerts a greater effect than an L-type Ca channel blocker verapamil, 21 dogs underwent rapid atrial pacing at 400 bpm for 14 days, pretreatment with efonidipine in 7 (E), verapamil in 7 (V), and none in 7 (C). We measured the atrial effective refractory period (ERP) serially during 14 days of rapid pacing. In response to rapid pacing, ERP decreased progressively in C. In contrast, in E and V, ERP remained greater than ERP in C (P < 0.01) on days 2 through 7. However, on the 14th day, ERP in V decreased to the level seen in C, whereas ERP in E remained significantly longer than ERPs in C or V (P < 0.01). The blockade L-type Ca channel alone is not sufficient, but the addition of a T-type Ca channel blockade shows a more sustained effect to prevent atrial electrical remodeling.

Original languageEnglish
Pages (from-to)386-392
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume44
Issue number3
DOIs
Publication statusPublished - 2004 Sep

Fingerprint

Atrial Remodeling
Calcium Channel Blockers
Verapamil
Down-Regulation
Dogs
Calcium
efonidipine

Keywords

  • Arrhythmia (mechanism)
  • Atrium
  • Ca channel blocker
  • Electrophysiology
  • T-type Ca channel

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. / Ohashi, Narutaka; Mitamura, Hideo; Tanimoto, Kojiro; Fukuda, Yukiko; Kinebuchi, Osamu; Kurita, Yasuo; Shiroshita-Takeshita, Akiko; Miyoshi, Shunichiro; Hara, Motoki; Takatsuki, Seiji; Ogawa, Satoshi.

In: Journal of Cardiovascular Pharmacology, Vol. 44, No. 3, 09.2004, p. 386-392.

Research output: Contribution to journalArticle

Ohashi, N, Mitamura, H, Tanimoto, K, Fukuda, Y, Kinebuchi, O, Kurita, Y, Shiroshita-Takeshita, A, Miyoshi, S, Hara, M, Takatsuki, S & Ogawa, S 2004, 'A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling', Journal of Cardiovascular Pharmacology, vol. 44, no. 3, pp. 386-392. https://doi.org/10.1097/01.fjc.0000138163.11612.7b
Ohashi, Narutaka ; Mitamura, Hideo ; Tanimoto, Kojiro ; Fukuda, Yukiko ; Kinebuchi, Osamu ; Kurita, Yasuo ; Shiroshita-Takeshita, Akiko ; Miyoshi, Shunichiro ; Hara, Motoki ; Takatsuki, Seiji ; Ogawa, Satoshi. / A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. In: Journal of Cardiovascular Pharmacology. 2004 ; Vol. 44, No. 3. pp. 386-392.
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