A comprehensive pathway map of epidermal growth factor receptor signaling.

Kanae Oda, Yukiko Matsuoka, Akira Funahashi, Hiroaki Kitano

Research output: Contribution to journalArticle

653 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well-defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).

Original languageEnglish
JournalMolecular systems biology [electronic resource].
Volume1
Publication statusPublished - 2005

Fingerprint

Growth Factors
Epidermal Growth Factor Receptor
Receptor
Pathway
Systems Biology
Markup languages
Molecular interactions
Signaling Pathways
Feedback Loop
Language
Software
Tie
Proliferation
Interaction
Dynamic Analysis
Computational Model
Dynamic analysis
Notation
Well-defined
Biological Sciences

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics
  • Information Systems
  • Applied Mathematics

Cite this

A comprehensive pathway map of epidermal growth factor receptor signaling. / Oda, Kanae; Matsuoka, Yukiko; Funahashi, Akira; Kitano, Hiroaki.

In: Molecular systems biology [electronic resource]., Vol. 1, 2005.

Research output: Contribution to journalArticle

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