A concise total synthesis of (±)-A80915G, a member of the napyradiomycin family of antibiotics

Shunji Takemura, Aya Hirayama, Junko Tokunaga, Fumie Kawamura, Kyoko Inagaki, Kimiko Hashimoto, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

(±)-A80915G, a member of the napyradiomycin family of antibiotics, has been synthesized from 1-amino-2,5-dimethoxy-4-nitrobenzene via the sequential palladium-catalyzed cross-coupling reactions (the Stille reaction) of aryl halides with allyltins and the Diels-Alder reaction of the chloroquinone with the Danishefsky-Brassard diene.

Original languageEnglish
Pages (from-to)7501-7505
Number of pages5
JournalTetrahedron Letters
Volume40
Issue number42
DOIs
Publication statusPublished - 1999 Oct 15

Keywords

  • Danishefsky-Brassard dienes
  • Diels-Alder reactions
  • Napyradiomycins
  • Stille reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A concise total synthesis of (±)-A80915G, a member of the napyradiomycin family of antibiotics'. Together they form a unique fingerprint.

Cite this