A contemporary snapshot of intestinal stem cells and their regulation

Ryo Seishima, Nick Barker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intestinal stem cells (ISCs) marked by Lgr5 are located at the bottom of the epithelial crypt compartment. Canonical Wnt signaling, activated by Wnt/Rspo ligands, determines the stem cell identity of Lgr5 + ISCs and is strictly regulated by the ISC niche. Emerging evidence indicates that both epithelial and stromal compartments provide the requisite Wnt/Rspo ligands, confining the ISC niche to the lower crypt regions of the intestine. Recent studies have also shown that the ISC niche can reprogram differentiated cells to replenish lost ISCs following tissue injury, accounting for the epithelial cell plasticity within the crypt compartment. Here we review these recent advances and discuss the role of canonical Wnt signaling in maintaining homeostasis and effecting cell plasticity following tissue injury in the intestine, which could reveal potential novel therapeutic opportunities in the clinic.

Original languageEnglish
JournalDifferentiation
DOIs
Publication statusAccepted/In press - 2019 Jan 1
Externally publishedYes

Fingerprint

Stem Cell Niche
Stem Cells
Intestines
Ligands
Wounds and Injuries
Homeostasis
Epithelial Cells
Cell Plasticity
Therapeutics

Keywords

  • Intestinal stem cell
  • Stem cell niche
  • Wnt signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

Cite this

A contemporary snapshot of intestinal stem cells and their regulation. / Seishima, Ryo; Barker, Nick.

In: Differentiation, 01.01.2019.

Research output: Contribution to journalArticle

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