A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor

Haruhito Kikuchi, Yoshikiyo Akasaka, Yoshihiro Kurosawa, Hiroshi Yoneyama, Shingo Kato, Jun ichi Hata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The WT1 gene is a tumor suppresser gene for Wilms' tumor (WT). Inactivation of both alleles has been proposed as the cause of WT. We encountered a patient with Denys-Drash syndrome associated with WT whose WT1 gene had a homozygous point mutation not only in WT but also in renal tissue adjacent to the WT and in the germline. These findings indicate that factor(s) other than the loss of WT1 are required for WT to develop.

Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalFEBS Letters
Volume360
Issue number1
DOIs
Publication statusPublished - 1995 Feb 20

Keywords

  • WT1 gene
  • Wilms' tumor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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