A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism

Tetsuo Nomiyama, Kazuyuki Omae, Shigeru Tanaka, Hiroyuki Miyauchi, Akio Koizumi, Mikako Tsukada, Yasuhiko Wada, Takashi Mogi, Shunichiro Imamiya, Haruhiko Sakurai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To summarize the results of two studies that attempted to clarify: (1) the health effects of hydrazine hydrate (HH) (N2H4·H2O: CAS No. 7803-57-8); and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH. Methods: A cross-sectional survey was carried out on 172 male HH-exposed workers and 125 male referent workers at five factories in Japan. The biological half-lives of HH after 1 h of exposure were determined in 12 workers, four workers in each of three NAT2 phenotypes. Clinical examinations were performed and acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires. NAT2 phenotypes were assessed. Results: No hydrazine was detected in either the breathing zones or the urine of the referent workers. The mean hydrazine concentration in the breathing zones, hydrazine and acetylhydrazine in urine, and the cumulative exposure level were 0.0109 ppm, 0.8660 μmol/g·Cr, and 2.80 ppm-years, respectively. There was no difference and no dose-dependent change in the health examination items between HH-exposed and referent workers after adjusting confounding factors, nor in terms of the differences of NAT2 phenotypes. Of 90 subjective symptoms, complaints of nightmares were significantly related to HH exposure. The half-life of urinary hydrazine and acetylhydrazine on rapid, intermediate, and slow phenotypes was 1.68, 3.01, and 4.46 h, respectively. Conclusion: This study suggested that current and cumulative exposure to HH did not affect the workers' health, and the half-life of the slow phenotype was longer than those of the rapid and intermediate phenotypes.

Original languageEnglish
JournalInternational Archives of Occupational and Environmental Health
Volume71
Issue numberSUPPL.
Publication statusPublished - 1998 Sep

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hydrazine
Observation
Health
Phenotype
Half-Life
Respiration
Urine

Keywords

  • Cross-sectional study
  • Epidemiology
  • Hydrazine hydrate
  • NAT2 polymorphism
  • Phenotype

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism. / Nomiyama, Tetsuo; Omae, Kazuyuki; Tanaka, Shigeru; Miyauchi, Hiroyuki; Koizumi, Akio; Tsukada, Mikako; Wada, Yasuhiko; Mogi, Takashi; Imamiya, Shunichiro; Sakurai, Haruhiko.

In: International Archives of Occupational and Environmental Health, Vol. 71, No. SUPPL., 09.1998.

Research output: Contribution to journalArticle

Nomiyama, T, Omae, K, Tanaka, S, Miyauchi, H, Koizumi, A, Tsukada, M, Wada, Y, Mogi, T, Imamiya, S & Sakurai, H 1998, 'A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism', International Archives of Occupational and Environmental Health, vol. 71, no. SUPPL..
Nomiyama, Tetsuo ; Omae, Kazuyuki ; Tanaka, Shigeru ; Miyauchi, Hiroyuki ; Koizumi, Akio ; Tsukada, Mikako ; Wada, Yasuhiko ; Mogi, Takashi ; Imamiya, Shunichiro ; Sakurai, Haruhiko. / A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism. In: International Archives of Occupational and Environmental Health. 1998 ; Vol. 71, No. SUPPL.
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abstract = "Objectives: To summarize the results of two studies that attempted to clarify: (1) the health effects of hydrazine hydrate (HH) (N2H4·H2O: CAS No. 7803-57-8); and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH. Methods: A cross-sectional survey was carried out on 172 male HH-exposed workers and 125 male referent workers at five factories in Japan. The biological half-lives of HH after 1 h of exposure were determined in 12 workers, four workers in each of three NAT2 phenotypes. Clinical examinations were performed and acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires. NAT2 phenotypes were assessed. Results: No hydrazine was detected in either the breathing zones or the urine of the referent workers. The mean hydrazine concentration in the breathing zones, hydrazine and acetylhydrazine in urine, and the cumulative exposure level were 0.0109 ppm, 0.8660 μmol/g·Cr, and 2.80 ppm-years, respectively. There was no difference and no dose-dependent change in the health examination items between HH-exposed and referent workers after adjusting confounding factors, nor in terms of the differences of NAT2 phenotypes. Of 90 subjective symptoms, complaints of nightmares were significantly related to HH exposure. The half-life of urinary hydrazine and acetylhydrazine on rapid, intermediate, and slow phenotypes was 1.68, 3.01, and 4.46 h, respectively. Conclusion: This study suggested that current and cumulative exposure to HH did not affect the workers' health, and the half-life of the slow phenotype was longer than those of the rapid and intermediate phenotypes.",
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AU - Nomiyama, Tetsuo

AU - Omae, Kazuyuki

AU - Tanaka, Shigeru

AU - Miyauchi, Hiroyuki

AU - Koizumi, Akio

AU - Tsukada, Mikako

AU - Wada, Yasuhiko

AU - Mogi, Takashi

AU - Imamiya, Shunichiro

AU - Sakurai, Haruhiko

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N2 - Objectives: To summarize the results of two studies that attempted to clarify: (1) the health effects of hydrazine hydrate (HH) (N2H4·H2O: CAS No. 7803-57-8); and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH. Methods: A cross-sectional survey was carried out on 172 male HH-exposed workers and 125 male referent workers at five factories in Japan. The biological half-lives of HH after 1 h of exposure were determined in 12 workers, four workers in each of three NAT2 phenotypes. Clinical examinations were performed and acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires. NAT2 phenotypes were assessed. Results: No hydrazine was detected in either the breathing zones or the urine of the referent workers. The mean hydrazine concentration in the breathing zones, hydrazine and acetylhydrazine in urine, and the cumulative exposure level were 0.0109 ppm, 0.8660 μmol/g·Cr, and 2.80 ppm-years, respectively. There was no difference and no dose-dependent change in the health examination items between HH-exposed and referent workers after adjusting confounding factors, nor in terms of the differences of NAT2 phenotypes. Of 90 subjective symptoms, complaints of nightmares were significantly related to HH exposure. The half-life of urinary hydrazine and acetylhydrazine on rapid, intermediate, and slow phenotypes was 1.68, 3.01, and 4.46 h, respectively. Conclusion: This study suggested that current and cumulative exposure to HH did not affect the workers' health, and the half-life of the slow phenotype was longer than those of the rapid and intermediate phenotypes.

AB - Objectives: To summarize the results of two studies that attempted to clarify: (1) the health effects of hydrazine hydrate (HH) (N2H4·H2O: CAS No. 7803-57-8); and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH. Methods: A cross-sectional survey was carried out on 172 male HH-exposed workers and 125 male referent workers at five factories in Japan. The biological half-lives of HH after 1 h of exposure were determined in 12 workers, four workers in each of three NAT2 phenotypes. Clinical examinations were performed and acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires. NAT2 phenotypes were assessed. Results: No hydrazine was detected in either the breathing zones or the urine of the referent workers. The mean hydrazine concentration in the breathing zones, hydrazine and acetylhydrazine in urine, and the cumulative exposure level were 0.0109 ppm, 0.8660 μmol/g·Cr, and 2.80 ppm-years, respectively. There was no difference and no dose-dependent change in the health examination items between HH-exposed and referent workers after adjusting confounding factors, nor in terms of the differences of NAT2 phenotypes. Of 90 subjective symptoms, complaints of nightmares were significantly related to HH exposure. The half-life of urinary hydrazine and acetylhydrazine on rapid, intermediate, and slow phenotypes was 1.68, 3.01, and 4.46 h, respectively. Conclusion: This study suggested that current and cumulative exposure to HH did not affect the workers' health, and the half-life of the slow phenotype was longer than those of the rapid and intermediate phenotypes.

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KW - Epidemiology

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KW - Phenotype

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