A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody

C. Morimoto, A. D. Steinberg, N. L. Letvin, M. Hagan, T. Takeuchi, J. Daley, H. Levine, S. F. Schlossman

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Abstract

The cell surface phenotype of peripheral blood lymphocytes (PBL) of systemic lupus erythematosus (SLE) patients was characterized with the anti-2H4 monoclonal antibody that defines the human suppressor inducer subset. The T4+2H4+ population of cells has been shown to be critical for the activation of T8+ suppressor cells. Patients with SLE had a markedly decreased percentage of T4+2H4+ cells (13 ± 2%) in their PBL compared with normal controls (21 ± 1%) (P < 0.001). This reduction was greatest in patients with active SLE, especially those with renal disease. Serial analysis of patients with SLE and renal disease showed a correlation between percent positive circulating T4+2H4+ cells and disease activity. Moreover, there was a significant correlation between a low percentage of T4+2H4+ cells and decreased suppressor-inducer function in autologous mixed lymphocyte reaction-activated T4+ cells from SLE patients. Thus, a deficiency exists in SLE patients with active renal disease in the T4+2H4+ suppressor-inducer T cell subset.

Original languageEnglish
Pages (from-to)762-768
Number of pages7
JournalJournal of Clinical Investigation
Volume79
Issue number3
DOIs
Publication statusPublished - 1987 Jan 1
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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