A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody

C. Morimoto, A. D. Steinberg, N. L. Letvin, M. Hagan, Tsutomu Takeuchi, J. Daley, H. Levine, S. F. Schlossman

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Abstract

The cell surface phenotype of peripheral blood lymphocytes (PBL) of systemic lupus erythematosus (SLE) patients was characterized with the anti-2H4 monoclonal antibody that defines the human suppressor inducer subset. The T4+2H4+ population of cells has been shown to be critical for the activation of T8+ suppressor cells. Patients with SLE had a markedly decreased percentage of T4+2H4+ cells (13 ± 2%) in their PBL compared with normal controls (21 ± 1%) (P < 0.001). This reduction was greatest in patients with active SLE, especially those with renal disease. Serial analysis of patients with SLE and renal disease showed a correlation between percent positive circulating T4+2H4+ cells and disease activity. Moreover, there was a significant correlation between a low percentage of T4+2H4+ cells and decreased suppressor-inducer function in autologous mixed lymphocyte reaction-activated T4+ cells from SLE patients. Thus, a deficiency exists in SLE patients with active renal disease in the T4+2H4+ suppressor-inducer T cell subset.

Original languageEnglish
Pages (from-to)762-768
Number of pages7
JournalJournal of Clinical Investigation
Volume79
Issue number3
Publication statusPublished - 1987
Externally publishedYes

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T-Lymphocyte Subsets
Systemic Lupus Erythematosus
CD4-Positive T-Lymphocytes
Anti-Idiotypic Antibodies
Kidney
CD8-Positive T-Lymphocytes
Lymphocytes
Mixed Lymphocyte Culture Test
Helper-Inducer T-Lymphocytes
Monoclonal Antibodies
Phenotype
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morimoto, C., Steinberg, A. D., Letvin, N. L., Hagan, M., Takeuchi, T., Daley, J., ... Schlossman, S. F. (1987). A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. Journal of Clinical Investigation, 79(3), 762-768.

A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. / Morimoto, C.; Steinberg, A. D.; Letvin, N. L.; Hagan, M.; Takeuchi, Tsutomu; Daley, J.; Levine, H.; Schlossman, S. F.

In: Journal of Clinical Investigation, Vol. 79, No. 3, 1987, p. 762-768.

Research output: Contribution to journalArticle

Morimoto, C, Steinberg, AD, Letvin, NL, Hagan, M, Takeuchi, T, Daley, J, Levine, H & Schlossman, SF 1987, 'A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody', Journal of Clinical Investigation, vol. 79, no. 3, pp. 762-768.
Morimoto, C. ; Steinberg, A. D. ; Letvin, N. L. ; Hagan, M. ; Takeuchi, Tsutomu ; Daley, J. ; Levine, H. ; Schlossman, S. F. / A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody. In: Journal of Clinical Investigation. 1987 ; Vol. 79, No. 3. pp. 762-768.
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AU - Levine, H.

AU - Schlossman, S. F.

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