A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

Masahiro Kubo, Hiroki Yotsuda, Taro Kosaka, Nobuhiko Nakano

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.

    Original languageEnglish
    Title of host publication2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Pages307-311
    Number of pages5
    ISBN (Print)9781467364997
    DOIs
    Publication statusPublished - 2016 Mar 11
    EventInternational Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 - Nusa Dua, Bali, Indonesia
    Duration: 2015 Nov 92015 Nov 12

    Other

    OtherInternational Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
    CountryIndonesia
    CityNusa Dua, Bali
    Period15/11/915/11/12

    Keywords

    • CMOS
    • LSI
    • OTA
    • Patch-clamp
    • recording
    • single-channel
    • TIA

    ASJC Scopus subject areas

    • Artificial Intelligence
    • Computer Networks and Communications
    • Signal Processing

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  • Cite this

    Kubo, M., Yotsuda, H., Kosaka, T., & Nakano, N. (2016). A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. In 2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 (pp. 307-311). [7432786] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISPACS.2015.7432786