A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

Masahiro Kubo; Hiroki Yotsuda; Taro Kosaka; Nobuhiko Nakano

doi:10.1109/ISPACS.2015.7432786

A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

Masahiro Kubo, Hiroki Yotsuda, Taro Kosaka, Nobuhiko Nakano

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.

Original language	English
Title of host publication	2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	307-311
Number of pages	5
ISBN (Print)	9781467364997
DOIs	https://doi.org/10.1109/ISPACS.2015.7432786
Publication status	Published - 2016 Mar 11
Event	International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 - Nusa Dua, Bali, Indonesia Duration: 2015 Nov 9 → 2015 Nov 12

Other

Other	International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015
Country/Territory	Indonesia
City	Nusa Dua, Bali
Period	15/11/9 → 15/11/12

Keywords

CMOS
LSI
OTA
Patch-clamp
recording
single-channel
TIA

ASJC Scopus subject areas

Artificial Intelligence
Computer Networks and Communications
Signal Processing

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10.1109/ISPACS.2015.7432786

Cite this

Kubo, M., Yotsuda, H., Kosaka, T., & Nakano, N. (2016). A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. In 2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015 (pp. 307-311). [7432786] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISPACS.2015.7432786

A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. / Kubo, Masahiro; Yotsuda, Hiroki; Kosaka, Taro et al.

2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015. Institute of Electrical and Electronics Engineers Inc., 2016. p. 307-311 7432786.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kubo, M, Yotsuda, H, Kosaka, T & Nakano, N 2016, A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system. in 2015 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015., 7432786, Institute of Electrical and Electronics Engineers Inc., pp. 307-311, International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2015, Nusa Dua, Bali, Indonesia, 15/11/9. https://doi.org/10.1109/ISPACS.2015.7432786

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abstract = "Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.",

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AB - Patch-clamp system is commonly used to measure ion current flowing through ion channel on cell membrane. By integration of this system, it is realized high density multi-channel system. In this paper, we designed Transimpedance Amplifier (TIA) in a patch-clamp system for single channel recording. Proposed TIA use OTA (Operational Transconductance Amplifier) as a feedback resistor, the size of TIA is drastically decreased compare to previously designed TIA using poly silicon resistor. The system was fabricated using the 0.18μm CMOS process. The designed size is 200 μm by 70 μm. We confirmed by simulation and measurement that the TIA has enough performance for single channel recording. The value of OTA resistance is variable from 5 MΩ to 500 MΩ by adjusting bias voltage. The bandwidth covers at least 10.3 kHz. Input-referred noise is 0.86 pArms in bandwidth that is extremely small value in on-chip transimpedance amplifiers for patch-clamp method. Power consumption of the TIA is 52.3 μW. Input range is ±50 pA when the value of resistance is 500MΩ.

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A design of Transimpedance Amplifier using OTA as a feedback resistor for patch-clamp measurement system

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