A direct role for Hsp90 in pre-RISC formation in Drosophila

Tomohiro Miyoshi, Akiko Takeuchi, Haruhiko Siomi, Mikiko C. Siomi

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complexĝ€" loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.

Original languageEnglish
Pages (from-to)1024-1026
Number of pages3
JournalNature Structural and Molecular Biology
Volume17
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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