A facile access to aryl α-sialosides: The combination of a volatile amine base and acetonitrile in glycosidation of sialosyl chlorides

Atsuhito Kuboki; Takahiro Sekiguchi; Takeshi Sugai; Hiromichi Ohta

doi:10.1055/s-1998-1717

A facile access to aryl α-sialosides: The combination of a volatile amine base and acetonitrile in glycosidation of sialosyl chlorides

Atsuhito Kuboki, Takahiro Sekiguchi, Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We have succeeded in achieving a facile access to 4-nitrophenyl and 4-methylumbelliferyl-α-sialosides. To sialosyl chlorides which are fully protected with acetyl groups as glycosyl donors, the action of phenols with diisopropylethylamine in acetonitrile brought about high yield as well as facile product isolation.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	Synlett
Issue number	5
DOIs	https://doi.org/10.1055/s-1998-1717
Publication status	Published - 1998 May

ASJC Scopus subject areas

Organic Chemistry

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abstract = "We have succeeded in achieving a facile access to 4-nitrophenyl and 4-methylumbelliferyl-α-sialosides. To sialosyl chlorides which are fully protected with acetyl groups as glycosyl donors, the action of phenols with diisopropylethylamine in acetonitrile brought about high yield as well as facile product isolation.",

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AU - Sugai, Takeshi

AU - Ohta, Hiromichi

PY - 1998/5

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AB - We have succeeded in achieving a facile access to 4-nitrophenyl and 4-methylumbelliferyl-α-sialosides. To sialosyl chlorides which are fully protected with acetyl groups as glycosyl donors, the action of phenols with diisopropylethylamine in acetonitrile brought about high yield as well as facile product isolation.

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A facile access to aryl α-sialosides: The combination of a volatile amine base and acetonitrile in glycosidation of sialosyl chlorides

Abstract

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