A general computational model of mitochondrial metabolism in a whole organelle scale

Katsuyuki Yugi, Masaru Tomita

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Summary: A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid β-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.

Original languageEnglish
Pages (from-to)1795-1796
Number of pages2
JournalBioinformatics
Volume20
Issue number11
DOIs
Publication statusPublished - 2004 Jul 22

Fingerprint

Systems Biology
Electron Transport
Metabolism
Organelles
Computational Model
Fatty Acids
Membranes
Enzymes
Enzyme Kinetics
Enzyme kinetics
Simulation System
Oxidation
Model
Metabolites
Simulation Model
Membrane
Fatty acids
Integrate
Cycle
Evaluate

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

A general computational model of mitochondrial metabolism in a whole organelle scale. / Yugi, Katsuyuki; Tomita, Masaru.

In: Bioinformatics, Vol. 20, No. 11, 22.07.2004, p. 1795-1796.

Research output: Contribution to journalArticle

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