A general computational model of mitochondrial metabolism in a whole organelle scale

Katsuyuki Yugi, Masaru Tomita

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Summary: A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid β-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.

Original languageEnglish
Pages (from-to)1795-1796
Number of pages2
JournalBioinformatics
Volume20
Issue number11
DOIs
Publication statusPublished - 2004 Jul 22

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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