A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population

Mai Kimura, Yuichi Tamura, Christophe Guignabert, Makoto Takei, Kenjiro Kosaki, Nobuhiro Tanabe, Koichiro Tatsumi, Tsutomu Saji, Toru Satoh, Masaharu Kataoka, Shigeo Kamitsuji, Naoyuki Kamatani, Raphaël Thuillet, Ly Tu, Marc Humbert, Keiichi Fukuda, Motoaki Sano

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5 Citations (Scopus)

Abstract

Pulmonary arterial hypertension (PAH) is a lethal disease that often affects the young. Although Bone Morphogenetic Protein Receptor Type 2 gene (BMPR2) mutations are related with idiopathic and heritable PAH, the low penetrance and variable expressivity in PAH suggest the existence of other genetic and/or environmental factors. In this study, we aimed to identify novel genetic factors associated with PAH, irrespective of BMPR2 mutation. We performed genome-wide association study (GWAS) in a Japanese population comprising 44 individuals with idiopathic and heritable PAH, and 2,993 controls. Seven loci identified in the genome-wide study were submitted to the validation study, and a novel susceptibility locus, PDE1A|DNAJC10, was identified that maps to 2q32.1 (rs71427857, P = 7.9 × 10-9, odds ratio in the validation study = 5.18; 95% CI 1.86 - 14.42). We also found the augmentation of PDE1A protein in distal remodeled pulmonary artery walls in idiopathic PAH patients. Given that phosphodiesterase 5 inhibitors are effective for the treatment of idiopathic and heritable PAH, our findings suggest that PDE1A could be a novel therapeutic target of PAH.

Original languageEnglish
Pages (from-to)74917-74926
Number of pages10
JournalOncotarget
Volume8
Issue number43
DOIs
Publication statusPublished - 2017

Keywords

  • Genome-wide association study
  • Novel therapeutic target
  • Pulmonary arterial hypertension

ASJC Scopus subject areas

  • Oncology

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    Kimura, M., Tamura, Y., Guignabert, C., Takei, M., Kosaki, K., Tanabe, N., Tatsumi, K., Saji, T., Satoh, T., Kataoka, M., Kamitsuji, S., Kamatani, N., Thuillet, R., Tu, L., Humbert, M., Fukuda, K., & Sano, M. (2017). A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population. Oncotarget, 8(43), 74917-74926. https://doi.org/10.18632/oncotarget.20459