A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Masashi Tomoda; RyōKo Gonda; Naoko Ōhara; Noriko Shimizu; Chiho Shishido; Yuka Fujiki

doi:10.1248/bpb.17.859

A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Masashi Tomoda, RyōKo Gonda, Naoko Ōhara, Noriko Shimizu, Chiho Shishido, Yuka Fujiki

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 10⁴. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.

Original language	English
Pages (from-to)	859-861
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	17
Issue number	6
DOIs	https://doi.org/10.1248/bpb.17.859
Publication status	Published - 1994

Keywords

Pinellia ternata
glucan
immunological activity
pinellian G
polysaccharide structure

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 104. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.",

keywords = "Pinellia ternata, glucan, immunological activity, pinellian G, polysaccharide structure",

author = "Masashi Tomoda and RyōKo Gonda and Naoko Ōhara and Noriko Shimizu and Chiho Shishido and Yuka Fujiki",

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AU - Tomoda, Masashi

AU - Gonda, RyōKo

AU - Ōhara, Naoko

AU - Shimizu, Noriko

AU - Shishido, Chiho

AU - Fujiki, Yuka

PY - 1994

Y1 - 1994

N2 - A glucan, called pinellian G, was isolated from the tuber of Pinellia ternata Breit. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 1.5 x 104. It is composed solely of D-glucose, in addition to a few O-acetyl groups. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it is a branched glucan mainly composed of α-l,4-linked D-glucopyranose residues with partially α-l,3-linked units and 4,6-branching points. The glucan showed significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as pronounced anti-complementary activity.

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KW - immunological activity

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KW - polysaccharide structure

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A Glucan Having Reticuloendothelial System-Potentiating and Anti-complementary Activities from the Tuber of Pinellia ternata

Abstract

Keywords

ASJC Scopus subject areas

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