A glucan with immunological activities from the tuber of Alisma orientale

N. Shimizu, S. Ohtsu, M. Tomoda, R. Gonda, N. Ohara

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A glucan, called alisman SI, was isolated from the tuber of Alisma orientale JUZEPCZ. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was 1.1 x 104. It is composed solely of D-glucose. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it has a high-branched glucan type structure mainly composed of α-1,4-linked D-glucopyranosyl residues with partially α-1,6-linked units and both 3,4- and 4,6-branching points. The polysaccharide exhibited significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a pronounced anti-complementary activity.

Original languageEnglish
Pages (from-to)1666-1668
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number12
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Alisma
Glucans
Mononuclear Phagocyte System
Methylation
Gel Chromatography
Polysaccharides
Electrophoresis
Magnetic Resonance Spectroscopy
Carbon
Glucose

Keywords

  • Alisma orientale
  • Alisman SI
  • Glucan
  • Immunological activity
  • Polysaccharide structure
  • Tuber

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A glucan with immunological activities from the tuber of Alisma orientale. / Shimizu, N.; Ohtsu, S.; Tomoda, M.; Gonda, R.; Ohara, N.

In: Biological and Pharmaceutical Bulletin, Vol. 17, No. 12, 1994, p. 1666-1668.

Research output: Contribution to journalArticle

Shimizu, N, Ohtsu, S, Tomoda, M, Gonda, R & Ohara, N 1994, 'A glucan with immunological activities from the tuber of Alisma orientale', Biological and Pharmaceutical Bulletin, vol. 17, no. 12, pp. 1666-1668.
Shimizu, N. ; Ohtsu, S. ; Tomoda, M. ; Gonda, R. ; Ohara, N. / A glucan with immunological activities from the tuber of Alisma orientale. In: Biological and Pharmaceutical Bulletin. 1994 ; Vol. 17, No. 12. pp. 1666-1668.
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