A Glucan with Immunological Activities from the Tuber of Alisma orientale

Noriko Shimizu, Sadanori Ohtsu, Masashi Tomoda, Ryōko Gonda, Naoko Ōhara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A glucan, called alisman SI, was isolated from the tuber of Alisma orientale Juzepcz. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was 1.1 x 104. It is composed solely of D-glucose. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it has a high-branched glucan type structure mainly composed of α-1,4-linked D-glucopyranosyl residues with partially α-1,6~linked units and both 3,4- and 4,6-branching points. The polysaccharide exhibited significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a pronounced anti-complementary activity.

Original languageEnglish
Pages (from-to)1666-1668
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number12
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Alisma orientale
  • alisman SI
  • glucan
  • immunological activity
  • polysaccharide structure
  • tube

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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