A glucan with immunological activities from the tuber of Alisma orientale

N. Shimizu, S. Ohtsu, M. Tomoda, R. Gonda, N. Ohara

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A glucan, called alisman SI, was isolated from the tuber of Alisma orientale JUZEPCZ. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was 1.1 x 104. It is composed solely of D-glucose. Methylation analysis, nuclear magnetic resonance and enzymic degradation studies indicated that it has a high-branched glucan type structure mainly composed of α-1,4-linked D-glucopyranosyl residues with partially α-1,6-linked units and both 3,4- and 4,6-branching points. The polysaccharide exhibited significant reticuloendothelial system-potentiating activity in a carbon clearance test, as well as a pronounced anti-complementary activity.

Original languageEnglish
Pages (from-to)1666-1668
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number12
Publication statusPublished - 1994
Externally publishedYes

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Keywords

  • Alisma orientale
  • Alisman SI
  • Glucan
  • Immunological activity
  • Polysaccharide structure
  • Tuber

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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