TY - JOUR
T1 - A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice
AU - Yokoyama, Yoko
AU - Nakamura, Takahiro J.
AU - Yoshimoto, Karen
AU - Ijyuin, Honoka
AU - Tachikawa, Naoyuki
AU - Oda, Haruka
AU - Shiraishi, Rena
AU - Shinohara, Kaori
AU - Kumadaki, Kayo
AU - Honda, Shiori
AU - Nakamura, Anna
AU - Kitamura, Naho
AU - Tsubota, Kazuo
AU - Watanabe, Mitsuhiro
N1 - Publisher Copyright:
© 2020 Yokoyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020/5
Y1 - 2020/5
N2 - Salt is an essential nutrient; however, excessive salt intake is a prominent public health concern worldwide. Various physiological functions are associated with circadian rhythms, and disruption of circadian rhythms is a prominent risk factor for cardiovascular diseases, cancer, and immune disease. Certain nutrients are vital regulators of peripheral circadian clocks. However, the role of a high-fat and high-salt (HFS) diet in the regulation of circadian gene expression is unclear. This study aimed to investigate the effect of an HFS diet on rhythms of locomotor activity, caecum glucocorticoid secretion, and clock gene expression in mice. Mice administered an HFS diet displayed reduced locomotor activity under normal light/dark and constant dark conditions in comparison with those administered a normal diet. The diurnal rhythm of caecum glucocorticoid secretion and the expression levels of glucocorticoid-related genes and clock genes in the adrenal gland were disrupted with an HFS diet. These results suggest that an HFS diet alters locomotor activity, disrupts circadian rhythms of glucocorticoid secretion, and downregulates peripheral adrenal gland circadian clock genes.
AB - Salt is an essential nutrient; however, excessive salt intake is a prominent public health concern worldwide. Various physiological functions are associated with circadian rhythms, and disruption of circadian rhythms is a prominent risk factor for cardiovascular diseases, cancer, and immune disease. Certain nutrients are vital regulators of peripheral circadian clocks. However, the role of a high-fat and high-salt (HFS) diet in the regulation of circadian gene expression is unclear. This study aimed to investigate the effect of an HFS diet on rhythms of locomotor activity, caecum glucocorticoid secretion, and clock gene expression in mice. Mice administered an HFS diet displayed reduced locomotor activity under normal light/dark and constant dark conditions in comparison with those administered a normal diet. The diurnal rhythm of caecum glucocorticoid secretion and the expression levels of glucocorticoid-related genes and clock genes in the adrenal gland were disrupted with an HFS diet. These results suggest that an HFS diet alters locomotor activity, disrupts circadian rhythms of glucocorticoid secretion, and downregulates peripheral adrenal gland circadian clock genes.
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U2 - 10.1371/journal.pone.0233386
DO - 10.1371/journal.pone.0233386
M3 - Article
C2 - 32437460
AN - SCOPUS:85085156219
SN - 1932-6203
VL - 15
JO - PLoS One
JF - PLoS One
IS - 5
M1 - e0233386
ER -
