A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Yasuyuki Nishiyama; Toru Hirota; Tetsuro Morisaki; Toshihiro Hara; Tomotoshi Marumoto; Shin Ichi Iida; Keishi Makino; Hideyuki Yamamoto; Takehisa Hiraoka; Nobuo Kitamura; Hideyuki Saya

doi:10.1016/S0014-5793(99)01224-7

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Yasuyuki Nishiyama, Toru Hirota, Tetsuro Morisaki, Toshihiro Hara, Tomotoshi Marumoto, Shin Ichi Iida, Keishi Makino, Hideyuki Yamamoto, Takehisa Hiraoka, Nobuo Kitamura, Hideyuki Saya

Division of Gene Regulation

Research output: Contribution to journal › Article

83 Citations (Scopus)

Abstract

We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.

Original language	English
Pages (from-to)	159-165
Number of pages	7
Journal	FEBS Letters
Volume	459
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(99)01224-7
Publication status	Published - 1999 Oct 8

Keywords

Cdc2
Centrosome
Chromosome 6q
Midbody
Mitotic spindle
Nocodazole

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Nishiyama, Y., Hirota, T., Morisaki, T., Hara, T., Marumoto, T., Iida, S. I., Makino, K., Yamamoto, H., Hiraoka, T., Kitamura, N., & Saya, H. (1999). A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Letters, 459(2), 159-165. https://doi.org/10.1016/S0014-5793(99)01224-7

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. / Nishiyama, Yasuyuki; Hirota, Toru; Morisaki, Tetsuro; Hara, Toshihiro; Marumoto, Tomotoshi; Iida, Shin Ichi; Makino, Keishi; Yamamoto, Hideyuki; Hiraoka, Takehisa; Kitamura, Nobuo; Saya, Hideyuki.

In: FEBS Letters, Vol. 459, No. 2, 08.10.1999, p. 159-165.

Research output: Contribution to journal › Article

Nishiyama, Yasuyuki ; Hirota, Toru ; Morisaki, Tetsuro ; Hara, Toshihiro ; Marumoto, Tomotoshi ; Iida, Shin Ichi ; Makino, Keishi ; Yamamoto, Hideyuki ; Hiraoka, Takehisa ; Kitamura, Nobuo ; Saya, Hideyuki. / A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. In: FEBS Letters. 1999 ; Vol. 459, No. 2. pp. 159-165.

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AU - Iida, Shin Ichi

AU - Makino, Keishi

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