Abstract
We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.
Original language | English |
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Pages (from-to) | 159-165 |
Number of pages | 7 |
Journal | FEBS Letters |
Volume | 459 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1999 Oct 8 |
Externally published | Yes |
Keywords
- Cdc2
- Centrosome
- Chromosome 6q
- Midbody
- Mitotic spindle
- Nocodazole
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology