A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

Yasuyuki Nishiyama, Toru Hirota, Tetsuro Morisaki, Toshihiro Hara, Tomotoshi Marumoto, Shin Ichi Iida, Keishi Makino, Hideyuki Yamamoto, Takehisa Hiraoka, Nobuo Kitamura, Hideyuki Saya

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83 Citations (Scopus)

Abstract

We identified a human homolog of Drosophila warts tumor suppressor gene, termed h-warts, which was mapped at chromosome 6q24-25.1. The h-warts protein has a serine/threonine kinase domain and is localized to centrosomes in interphase cells. However, it becomes localized to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, in a highly dynamic manner during mitosis. Furthermore, h-warts is specifically phosphorylated in cells at mitotic phase, most likely by Cdc2 kinase. These findings suggest that h-warts functions as a component of the mitotic apparatus and is involved in proper progression of mitosis.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalFEBS Letters
Volume459
Issue number2
DOIs
Publication statusPublished - 1999 Oct 8

Keywords

  • Cdc2
  • Centrosome
  • Chromosome 6q
  • Midbody
  • Mitotic spindle
  • Nocodazole

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Nishiyama, Y., Hirota, T., Morisaki, T., Hara, T., Marumoto, T., Iida, S. I., Makino, K., Yamamoto, H., Hiraoka, T., Kitamura, N., & Saya, H. (1999). A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. FEBS Letters, 459(2), 159-165. https://doi.org/10.1016/S0014-5793(99)01224-7