Abstract
Wu and colleagues create a double-knockin human TBX5Clover2 and NKX2-5TagRFP reporter to delineate cardiac lineages during differentiation. Molecular and functional analyses uncover that differential expression of TBX5 and NKX2-5 specifies different cardiac fate. This reporter is applicable for studying cardiac lineage determination in vitro and isolating cardiac subpopulations.
Original language | English |
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Pages (from-to) | 802-811.e5 |
Journal | Cell stem cell |
Volume | 24 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2019 May 2 |
Keywords
- CORIN
- NKX2-5
- TBX5
- cardiomyocyte subtypes
- endothelial cell lineage
- epicardial lineage
- hiPSC double reporter
- human first and second heart field
- precise drug testing
- purification
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Cell Biology