A hypothesis for myeloschisis: Overgrowth and reopening. An experimental study

S. Oi, Hideyuki Saya, S. Matsumoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A hypothesis for embryopathogenesis of myeloschisis is described on the basis of experimental studies analyzing the stage specificity and immunohistochemical/histological characteristics of the exposed neural tissue (placode). Myeloschisis developed in six fetuses among 205 chick embryos treated in various stages with teratogens including ethylnitrosourea, and anticonvulsant and antipyretic agents. All but one case (with associated cephalothoracopagus) demonstrated myeloschisis in the thoracic region with a lamina defect of two and three levels. No fetus was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the neuropore closes. Immunohistochemical studies of chick myeloschisis clearly indicated that neuron-specific enolase-positive elements were extremely active only in the overgrown placode, corresponding to the histological findings with Kluver-Barrerra's special stain. These findings were compared with observations in a case of myeloschisis in a human neonate. The results of this study imply the possibility of another mechanism for the embryopathogenesis of myeloschisis: namely, the overgrowth and reopening hypothesis.

Original languageEnglish
Pages (from-to)947-954
Number of pages8
JournalJournal of Neurosurgery
Volume68
Issue number6
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Teratogens
Fetus
Ethylnitrosourea
Antipyretics
Phosphopyruvate Hydratase
Chick Embryo
Anticonvulsants
Coloring Agents
Thorax

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

A hypothesis for myeloschisis : Overgrowth and reopening. An experimental study. / Oi, S.; Saya, Hideyuki; Matsumoto, S.

In: Journal of Neurosurgery, Vol. 68, No. 6, 1988, p. 947-954.

Research output: Contribution to journalArticle

@article{a73ad1538055432c8550d9e96696ad2d,
title = "A hypothesis for myeloschisis: Overgrowth and reopening. An experimental study",
abstract = "A hypothesis for embryopathogenesis of myeloschisis is described on the basis of experimental studies analyzing the stage specificity and immunohistochemical/histological characteristics of the exposed neural tissue (placode). Myeloschisis developed in six fetuses among 205 chick embryos treated in various stages with teratogens including ethylnitrosourea, and anticonvulsant and antipyretic agents. All but one case (with associated cephalothoracopagus) demonstrated myeloschisis in the thoracic region with a lamina defect of two and three levels. No fetus was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the neuropore closes. Immunohistochemical studies of chick myeloschisis clearly indicated that neuron-specific enolase-positive elements were extremely active only in the overgrown placode, corresponding to the histological findings with Kluver-Barrerra's special stain. These findings were compared with observations in a case of myeloschisis in a human neonate. The results of this study imply the possibility of another mechanism for the embryopathogenesis of myeloschisis: namely, the overgrowth and reopening hypothesis.",
author = "S. Oi and Hideyuki Saya and S. Matsumoto",
year = "1988",
language = "English",
volume = "68",
pages = "947--954",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "6",

}

TY - JOUR

T1 - A hypothesis for myeloschisis

T2 - Overgrowth and reopening. An experimental study

AU - Oi, S.

AU - Saya, Hideyuki

AU - Matsumoto, S.

PY - 1988

Y1 - 1988

N2 - A hypothesis for embryopathogenesis of myeloschisis is described on the basis of experimental studies analyzing the stage specificity and immunohistochemical/histological characteristics of the exposed neural tissue (placode). Myeloschisis developed in six fetuses among 205 chick embryos treated in various stages with teratogens including ethylnitrosourea, and anticonvulsant and antipyretic agents. All but one case (with associated cephalothoracopagus) demonstrated myeloschisis in the thoracic region with a lamina defect of two and three levels. No fetus was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the neuropore closes. Immunohistochemical studies of chick myeloschisis clearly indicated that neuron-specific enolase-positive elements were extremely active only in the overgrown placode, corresponding to the histological findings with Kluver-Barrerra's special stain. These findings were compared with observations in a case of myeloschisis in a human neonate. The results of this study imply the possibility of another mechanism for the embryopathogenesis of myeloschisis: namely, the overgrowth and reopening hypothesis.

AB - A hypothesis for embryopathogenesis of myeloschisis is described on the basis of experimental studies analyzing the stage specificity and immunohistochemical/histological characteristics of the exposed neural tissue (placode). Myeloschisis developed in six fetuses among 205 chick embryos treated in various stages with teratogens including ethylnitrosourea, and anticonvulsant and antipyretic agents. All but one case (with associated cephalothoracopagus) demonstrated myeloschisis in the thoracic region with a lamina defect of two and three levels. No fetus was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the neuropore closes. Immunohistochemical studies of chick myeloschisis clearly indicated that neuron-specific enolase-positive elements were extremely active only in the overgrown placode, corresponding to the histological findings with Kluver-Barrerra's special stain. These findings were compared with observations in a case of myeloschisis in a human neonate. The results of this study imply the possibility of another mechanism for the embryopathogenesis of myeloschisis: namely, the overgrowth and reopening hypothesis.

UR - http://www.scopus.com/inward/record.url?scp=0023938720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023938720&partnerID=8YFLogxK

M3 - Article

C2 - 3373289

AN - SCOPUS:0023938720

VL - 68

SP - 947

EP - 954

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 6

ER -