A large coronary aneurysm and its probable precursor lesions in a patient with autosomal dominant polycystic kidney disease

An implication for the process of aneurysmogenesis

Kentaro Ohara, Tokuhiro Kimura, Takaaki Karasawa, Hirobumi Tokuyama, Shu Wakino, Koichi Hayashi, Hiroshi Itoh, Yasunori Okada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Coronary artery aneurysms are rare complications of autosomal dominant polycystic kidney disease (ADPKD), and their pathogenesis remains poorly understood. We report an autopsy case of a 64-year-old ADPKD patient with an asymptomatic, large (4cm in diameter) saccular aneurysm arising from the left circumflex (LCX) branch of the coronary artery with only mild atherosclerotic changes. Autopsy also revealed small, focal defects of media with or without microaneurysm formation in the LCX, mesenteric and renal arteries, and a fibromuscular dysplasia-like lesion with microaneurysm in the common iliac artery. Since polycystin-1 and -2 are expressed in arterial smooth-muscle cells, these findings imply that abnormal polycystin expression in ADPKD initially causes the focal medial defects, some of which might later progress to microaneurysms and then overt aneurysms. To the best of our knowledge, this is the first description of the pathologic findings of an ADPKD-associated coronary aneurysm and its probable precursor lesions in arteries.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalPathology International
Volume62
Issue number11
DOIs
Publication statusPublished - 2012 Nov

Fingerprint

Coronary Aneurysm
Autosomal Dominant Polycystic Kidney
Aneurysm
Autopsy
Coronary Vessels
TRPP Cation Channels
Fibromuscular Dysplasia
Mesenteric Arteries
Iliac Artery
Renal Artery
Smooth Muscle Myocytes
Arteries
Microaneurysm

Keywords

  • Aneurysm
  • Autosomal dominant polycystic kidney disease
  • Coronary artery
  • Medial defect

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A large coronary aneurysm and its probable precursor lesions in a patient with autosomal dominant polycystic kidney disease : An implication for the process of aneurysmogenesis. / Ohara, Kentaro; Kimura, Tokuhiro; Karasawa, Takaaki; Tokuyama, Hirobumi; Wakino, Shu; Hayashi, Koichi; Itoh, Hiroshi; Okada, Yasunori.

In: Pathology International, Vol. 62, No. 11, 11.2012, p. 758-762.

Research output: Contribution to journalArticle

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