TY - JOUR
T1 - A lipidome atlas in MS-DIAL 4
AU - Tsugawa, Hiroshi
AU - Ikeda, Kazutaka
AU - Takahashi, Mikiko
AU - Satoh, Aya
AU - Mori, Yoshifumi
AU - Uchino, Haruki
AU - Okahashi, Nobuyuki
AU - Yamada, Yutaka
AU - Tada, Ipputa
AU - Bonini, Paolo
AU - Higashi, Yasuhiro
AU - Okazaki, Yozo
AU - Zhou, Zhiwei
AU - Zhu, Zheng Jiang
AU - Koelmel, Jeremy
AU - Cajka, Tomas
AU - Fiehn, Oliver
AU - Saito, Kazuki
AU - Arita, Masanori
AU - Arita, Makoto
N1 - Funding Information:
This work was mainly supported by the JSPS Grant-in-Aid for Scientific Research on Innovative Areas ‘LipoQuality’ (grant nos. 15H05897, 15H05898 to Makoto Arita). This work was partially supported by AMED-LEAP under grant no. JP18gm0010003 (to Makoto Arita), RIKEN Pioneering Project ‘Glyco-lipidologue Initiative’ (to Masanori Arita and Makoto Arita), JSPS KAKENHI (grant nos. 18H02432, 18K19155 for H.T.), JST National Bioscience Database Center (NBDC to Masanori Arita), the Czech Science Foundation (grant no. 20-21114S to T.C.) and the Czech Ministry of Education, Youth and Sports (grant no. LTAUSA19124 to T.C.). We thank S. Madden and J. Fjeldsted (Agilent Technologies) for sharing the MIDAC SDK, S. Brehmer (Bruker) for sharing the tims SDK and the Waters developmental team for sharing the SDK for traveling wave ion mobility data. We thank X. Li for his help in validating MS-DIAL libraries. We also thank K. Takano and A. Hori (RIKEN) for LC–MS analysis, N. Hoffmann and S. Neumann (Leibniz Institute) for the discussion of mztab-M export and G. Liebisch (University Hospital Regensburg) for the discussion of lipid nomenclature.
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and tandem mass spectrometry information. We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and included ion mobility tandem mass spectrometry. Using human, murine, algal and plant biological samples, we annotated and semiquantified 8,051 lipids using MS-DIAL 4 with a 1–2% estimated false discovery rate. MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.
AB - We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and tandem mass spectrometry information. We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and included ion mobility tandem mass spectrometry. Using human, murine, algal and plant biological samples, we annotated and semiquantified 8,051 lipids using MS-DIAL 4 with a 1–2% estimated false discovery rate. MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.
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U2 - 10.1038/s41587-020-0531-2
DO - 10.1038/s41587-020-0531-2
M3 - Article
C2 - 32541957
AN - SCOPUS:85086461688
SN - 1087-0156
VL - 38
SP - 1159
EP - 1163
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 10
ER -