A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency

Yuri Moriyama, Tomonori Okamura, Akihiro Inazu, Mitsunori Doi, Hiroyasu Iso, Yoshitaka Mouri, Yoshinori Ishikawa, Hideyoshi Suzuki, Minoru Iida, Junji Koizumi, Hiroshi Mabuchi, Yoshio Komachi

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Background. Use of genetic analysis may improve the predictive value of risk factors for disease. A high plasma level of high-density lipoprotein (HDL) cholesterol is a strong negative risk factor for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) deficiency causes increased levels of HDL cholesterol. However, recent studies suggest that CETP deficiency is a risk factor for CHD despite elevated HDL cholesterol levels. Methods. Plasma lipid levels, CHD prevalence, resting electrocardiograms, and common CETP gene mutations were analyzed cross-sectionally in a population of 19,044 male and 29,487 female Japanese subjects (ages 45-79 years). Results. High HDL cholesterol levels (serum HDL cholesterol ≤80 mg/dl, ≤95th percentile) were found in 6 and 5% of Japanese men and women, respectively. In the group with HDL cholesterol ≤80 mg/dl, common CETP gene mutations were identified in 23-24% of men and 31-49% of women. The prevalence of CHD in the group with high HDL cholesterol (≤80 mg/dl) was low among both men (1.0%) and women (1.3%). There was no difference in CHD prevalence between hyper- HDL-cholesterolemic subjects with and without CETP mutations. Conclusions. Subjects with very high HDL levels (HDL cholesterol ≤80 mg/dl) as well as mild-to-moderate HDL elevations (60-79 mg/dl) appear to be protected against CHD, whether or not they have CETP deficiency, a genetic cause of elevated HDL.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalPreventive Medicine
Volume27
Issue number5 I
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

HDL Cholesterol
Coronary Disease
Blood Proteins
HDL Lipoproteins
Cholesterol Ester Transfer Proteins
Mutation
Cholesteryl Ester Transfer Protein Deficiency
Genes
Electrocardiography
Lipids
Serum
Population

Keywords

  • Cholesterol
  • Cholesteryl ester transfer protein deficiency
  • Coronary heart disease
  • Genetic epidemiology
  • High-density lipoprotein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency. / Moriyama, Yuri; Okamura, Tomonori; Inazu, Akihiro; Doi, Mitsunori; Iso, Hiroyasu; Mouri, Yoshitaka; Ishikawa, Yoshinori; Suzuki, Hideyoshi; Iida, Minoru; Koizumi, Junji; Mabuchi, Hiroshi; Komachi, Yoshio.

In: Preventive Medicine, Vol. 27, No. 5 I, 1998, p. 659-667.

Research output: Contribution to journalArticle

Moriyama, Yuri ; Okamura, Tomonori ; Inazu, Akihiro ; Doi, Mitsunori ; Iso, Hiroyasu ; Mouri, Yoshitaka ; Ishikawa, Yoshinori ; Suzuki, Hideyoshi ; Iida, Minoru ; Koizumi, Junji ; Mabuchi, Hiroshi ; Komachi, Yoshio. / A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency. In: Preventive Medicine. 1998 ; Vol. 27, No. 5 I. pp. 659-667.
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abstract = "Background. Use of genetic analysis may improve the predictive value of risk factors for disease. A high plasma level of high-density lipoprotein (HDL) cholesterol is a strong negative risk factor for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) deficiency causes increased levels of HDL cholesterol. However, recent studies suggest that CETP deficiency is a risk factor for CHD despite elevated HDL cholesterol levels. Methods. Plasma lipid levels, CHD prevalence, resting electrocardiograms, and common CETP gene mutations were analyzed cross-sectionally in a population of 19,044 male and 29,487 female Japanese subjects (ages 45-79 years). Results. High HDL cholesterol levels (serum HDL cholesterol ≤80 mg/dl, ≤95th percentile) were found in 6 and 5{\%} of Japanese men and women, respectively. In the group with HDL cholesterol ≤80 mg/dl, common CETP gene mutations were identified in 23-24{\%} of men and 31-49{\%} of women. The prevalence of CHD in the group with high HDL cholesterol (≤80 mg/dl) was low among both men (1.0{\%}) and women (1.3{\%}). There was no difference in CHD prevalence between hyper- HDL-cholesterolemic subjects with and without CETP mutations. Conclusions. Subjects with very high HDL levels (HDL cholesterol ≤80 mg/dl) as well as mild-to-moderate HDL elevations (60-79 mg/dl) appear to be protected against CHD, whether or not they have CETP deficiency, a genetic cause of elevated HDL.",
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T1 - A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency

AU - Moriyama, Yuri

AU - Okamura, Tomonori

AU - Inazu, Akihiro

AU - Doi, Mitsunori

AU - Iso, Hiroyasu

AU - Mouri, Yoshitaka

AU - Ishikawa, Yoshinori

AU - Suzuki, Hideyoshi

AU - Iida, Minoru

AU - Koizumi, Junji

AU - Mabuchi, Hiroshi

AU - Komachi, Yoshio

PY - 1998

Y1 - 1998

N2 - Background. Use of genetic analysis may improve the predictive value of risk factors for disease. A high plasma level of high-density lipoprotein (HDL) cholesterol is a strong negative risk factor for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) deficiency causes increased levels of HDL cholesterol. However, recent studies suggest that CETP deficiency is a risk factor for CHD despite elevated HDL cholesterol levels. Methods. Plasma lipid levels, CHD prevalence, resting electrocardiograms, and common CETP gene mutations were analyzed cross-sectionally in a population of 19,044 male and 29,487 female Japanese subjects (ages 45-79 years). Results. High HDL cholesterol levels (serum HDL cholesterol ≤80 mg/dl, ≤95th percentile) were found in 6 and 5% of Japanese men and women, respectively. In the group with HDL cholesterol ≤80 mg/dl, common CETP gene mutations were identified in 23-24% of men and 31-49% of women. The prevalence of CHD in the group with high HDL cholesterol (≤80 mg/dl) was low among both men (1.0%) and women (1.3%). There was no difference in CHD prevalence between hyper- HDL-cholesterolemic subjects with and without CETP mutations. Conclusions. Subjects with very high HDL levels (HDL cholesterol ≤80 mg/dl) as well as mild-to-moderate HDL elevations (60-79 mg/dl) appear to be protected against CHD, whether or not they have CETP deficiency, a genetic cause of elevated HDL.

AB - Background. Use of genetic analysis may improve the predictive value of risk factors for disease. A high plasma level of high-density lipoprotein (HDL) cholesterol is a strong negative risk factor for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) deficiency causes increased levels of HDL cholesterol. However, recent studies suggest that CETP deficiency is a risk factor for CHD despite elevated HDL cholesterol levels. Methods. Plasma lipid levels, CHD prevalence, resting electrocardiograms, and common CETP gene mutations were analyzed cross-sectionally in a population of 19,044 male and 29,487 female Japanese subjects (ages 45-79 years). Results. High HDL cholesterol levels (serum HDL cholesterol ≤80 mg/dl, ≤95th percentile) were found in 6 and 5% of Japanese men and women, respectively. In the group with HDL cholesterol ≤80 mg/dl, common CETP gene mutations were identified in 23-24% of men and 31-49% of women. The prevalence of CHD in the group with high HDL cholesterol (≤80 mg/dl) was low among both men (1.0%) and women (1.3%). There was no difference in CHD prevalence between hyper- HDL-cholesterolemic subjects with and without CETP mutations. Conclusions. Subjects with very high HDL levels (HDL cholesterol ≤80 mg/dl) as well as mild-to-moderate HDL elevations (60-79 mg/dl) appear to be protected against CHD, whether or not they have CETP deficiency, a genetic cause of elevated HDL.

KW - Cholesterol

KW - Cholesteryl ester transfer protein deficiency

KW - Coronary heart disease

KW - Genetic epidemiology

KW - High-density lipoprotein

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U2 - 10.1006/pmed.1998.0340

DO - 10.1006/pmed.1998.0340

M3 - Article

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VL - 27

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JO - Preventive Medicine

JF - Preventive Medicine

SN - 0091-7435

IS - 5 I

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