A microfilter utilizing a polyethersulfone porous membrane with nanopores

Research output: Contribution to journalArticle

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Abstract

We present a novel microfilter system used for the selective separation of solutes of molecular sizes 1-2 nm. The microfilter system consists of two layers of micro chambers made of PDMS and one piece of porous membrane made of polyethersulfone (PES) using the wet-phase inversion method. The PES membrane at the center of the two micro chambers acts as a barrier to molecules larger than its pores. A novel method of bonding the PES membrane to PDMS surface was developed in the device fabrication, whereby diffusion in the microfilter was theoretically derived and applied in the filtering evaluation. The filtering capacity of this microfilter for molecules of molecular sizes from 0.3 nm to 6.6 nm was evaluated using solution samples of sodium chloride (NaCl) and fluorescein isothiocyanate (FITC) dextrans with molecular weights of 4k, 20k and 70k, respectively. The filtering experiments indicated that the optimal membrane used for the device was P2S2. This microfilter system with optimal PES membrane was believed to be capable of selective separation at a molecular size barrier of 1-2 nm and also believed to have the potential for use in portable hemodialysis systems.

Original languageEnglish
Pages (from-to)2308-2315
Number of pages8
JournalJournal of Micromechanics and Microengineering
Volume17
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1
Externally publishedYes

Fingerprint

Nanopores
membranes
Membranes
chambers
Molecules
dextrans
Dextran
sodium chlorides
Sodium chloride
Sodium Chloride
molecules
molecular weight
solutes
Molecular weight
polyether sulfone
inversions
porosity
Fabrication
fabrication
evaluation

ASJC Scopus subject areas

  • Instrumentation
  • Materials Science(all)
  • Mechanics of Materials
  • Computational Mechanics

Cite this

A microfilter utilizing a polyethersulfone porous membrane with nanopores. / Gu, Ye; Miki, Norihisa.

In: Journal of Micromechanics and Microengineering, Vol. 17, No. 11, 01.11.2007, p. 2308-2315.

Research output: Contribution to journalArticle

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