A microfluidic organoid trapping device to form tube-like intestinal organoids

Miki Matsumoto, Yuya Morimoto, Toshiro Sato, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose an organoid-trapping device to form long intestinal epithelial organoids. The device is drivable with hydrostatic pressure to gather standard organoids, and induces their fusion in the microchannel. We can control the length of the tube-like organoids by adjusting the number of standard organoids. As a demonstration, six organoids were trapped in the device and tube-like organoids were formed by their fusion within two days. Our device will provide desired length of organoids for development of a perfusable 3D intestinal organoid model.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages871-872
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • Fusion
  • Intestinal organoid
  • Microfluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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