A microscale synthesis of a promising radiolabelled antitumor drug: Cis‐1,1‐cyclobutanedicarboxylato (2R)‐2‐methyl‐1,4‐butanediamine platinum(II), NK121

Masato Suwa, Osamu Kogawa, Hiroyoshi Nowatari, Yuko Morita-Murase, Yoshio Homma, Yutaka Hashimoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A promising antitumor drug, cis‐1,1‐cyclobutane‐dicarboxylato (2R)‐2‐methyl‐1,4‐butanediamine platinum(II), NK121, was synthesized from radionuclides of platinum such as 193mPt, 195mPt and 191Pt which were produced by neutron irradiation of enriched 192Pt. The overall yield was 38.6% in a synthesis time of 10 hours. The radioactivities present in 8.39 mg of NK121 were 115.3 μCi as 193mPt, 29.9 μCi as 197Pt, 22.0 μCi as 195mPt, and 4.8 μCi as 191Pt at the end of synthesis. The specific activity of the NK121 was 13.7 μCi (193mPt)/mg NK121 at the end of synthesis. The radiochemical purity of NK121 was typically 99 %. HPLC analyses confirmed that NK121 was in an adequate chemical purity and suitable for animal experimentation.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume31
Issue number5
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Platinum
Antineoplastic Agents
Neutron irradiation
Radioactivity
Neutrons
Radioisotopes
NK 121
Animals
High Pressure Liquid Chromatography

Keywords

  • Pt‐labelled antitumor drug
  • microscale synthesis
  • NK121

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

A microscale synthesis of a promising radiolabelled antitumor drug : Cis‐1,1‐cyclobutanedicarboxylato (2R)‐2‐methyl‐1,4‐butanediamine platinum(II), NK121. / Suwa, Masato; Kogawa, Osamu; Nowatari, Hiroyoshi; Morita-Murase, Yuko; Homma, Yoshio; Hashimoto, Yutaka.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 31, No. 5, 1992, p. 349-354.

Research output: Contribution to journalArticle

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