A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding

Osamu Goto, Mitsuhiro Fujishiro, Ichiro Oda, Naomi Kakushima, Yorimasa Yamamoto, Yosuke Tsuji, Ken Ohata, Takashi Fujiwara, Junko Fujiwara, Naoki Ishii, Chizu Yokoi, Shinichi Miyamoto, Toshiyuki Itoh, Shinji Morishita, Takuji Gotoda, Kazuhiko Koike

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background and Aims: Bleeding is a major complication after gastric endoscopic submucosal dissection (ESD). An evidence-based strategy for postoperative care related to delayed bleeding is required. We conducted a multicenter survey to assess the current status of management after gastric ESD. Methods: A total of 1,814 gastric epithelial neoplasms in 2009 at ten tertiary referral centers were enrolled. The current status of the management after gastric ESD (use of an antisecretory drug, food intake, and second-look endoscopy) at participating hospitals was assessed. Furthermore, the rate of post-ESD bleeding and the differences in each parameter were retrospectively analyzed. Results: Postoperative bleeding occurred in 100 cases (5.5%), which included 62 cases of bleeding within 24 h after ESD. In all of the hospitals, proton pump inhibitors (PPIs) were used. The median administration period was 56 days (range 14-60 days). Food intake was resumed from postoperative day (POD) 1 in 4 hospitals and from POD 2 in 6 hospitals. Second-look endoscopy was performed for almost all cases, fewer cases, and rarely or none in 6, 2, and 2 hospitals, respectively. The day of second-look endoscopy varied among hospitals. There was no statistical relationship between the postoperative bleeding rate and the differences in these three parameters. Conclusions: Post-ESD management (duration of PPI use, resumption of food intake, and performance of second-look endoscopy) varied among the medical centers; thus, randomized controlled trials are required for an optimal strategy after gastric ESD.

Original languageEnglish
Pages (from-to)435-439
Number of pages5
JournalDigestive Diseases and Sciences
Volume57
Issue number2
DOIs
Publication statusPublished - 2012 Feb
Externally publishedYes

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Stomach
Hemorrhage
Endoscopy
Eating
Proton Pump Inhibitors
Glandular and Epithelial Neoplasms
Postoperative Care
Surveys and Questionnaires
Endoscopic Mucosal Resection
Tertiary Care Centers
Stomach Neoplasms
Randomized Controlled Trials
Pharmaceutical Preparations

Keywords

  • Endoscopic submucosal dissection
  • Gastric epithelial neoplasms
  • Postoperative bleeding
  • Second-look endoscopy

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. / Goto, Osamu; Fujishiro, Mitsuhiro; Oda, Ichiro; Kakushima, Naomi; Yamamoto, Yorimasa; Tsuji, Yosuke; Ohata, Ken; Fujiwara, Takashi; Fujiwara, Junko; Ishii, Naoki; Yokoi, Chizu; Miyamoto, Shinichi; Itoh, Toshiyuki; Morishita, Shinji; Gotoda, Takuji; Koike, Kazuhiko.

In: Digestive Diseases and Sciences, Vol. 57, No. 2, 02.2012, p. 435-439.

Research output: Contribution to journalArticle

Goto, O, Fujishiro, M, Oda, I, Kakushima, N, Yamamoto, Y, Tsuji, Y, Ohata, K, Fujiwara, T, Fujiwara, J, Ishii, N, Yokoi, C, Miyamoto, S, Itoh, T, Morishita, S, Gotoda, T & Koike, K 2012, 'A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding', Digestive Diseases and Sciences, vol. 57, no. 2, pp. 435-439. https://doi.org/10.1007/s10620-011-1886-5
Goto, Osamu ; Fujishiro, Mitsuhiro ; Oda, Ichiro ; Kakushima, Naomi ; Yamamoto, Yorimasa ; Tsuji, Yosuke ; Ohata, Ken ; Fujiwara, Takashi ; Fujiwara, Junko ; Ishii, Naoki ; Yokoi, Chizu ; Miyamoto, Shinichi ; Itoh, Toshiyuki ; Morishita, Shinji ; Gotoda, Takuji ; Koike, Kazuhiko. / A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. In: Digestive Diseases and Sciences. 2012 ; Vol. 57, No. 2. pp. 435-439.
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AU - Goto, Osamu

AU - Fujishiro, Mitsuhiro

AU - Oda, Ichiro

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AU - Yamamoto, Yorimasa

AU - Tsuji, Yosuke

AU - Ohata, Ken

AU - Fujiwara, Takashi

AU - Fujiwara, Junko

AU - Ishii, Naoki

AU - Yokoi, Chizu

AU - Miyamoto, Shinichi

AU - Itoh, Toshiyuki

AU - Morishita, Shinji

AU - Gotoda, Takuji

AU - Koike, Kazuhiko

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N2 - Background and Aims: Bleeding is a major complication after gastric endoscopic submucosal dissection (ESD). An evidence-based strategy for postoperative care related to delayed bleeding is required. We conducted a multicenter survey to assess the current status of management after gastric ESD. Methods: A total of 1,814 gastric epithelial neoplasms in 2009 at ten tertiary referral centers were enrolled. The current status of the management after gastric ESD (use of an antisecretory drug, food intake, and second-look endoscopy) at participating hospitals was assessed. Furthermore, the rate of post-ESD bleeding and the differences in each parameter were retrospectively analyzed. Results: Postoperative bleeding occurred in 100 cases (5.5%), which included 62 cases of bleeding within 24 h after ESD. In all of the hospitals, proton pump inhibitors (PPIs) were used. The median administration period was 56 days (range 14-60 days). Food intake was resumed from postoperative day (POD) 1 in 4 hospitals and from POD 2 in 6 hospitals. Second-look endoscopy was performed for almost all cases, fewer cases, and rarely or none in 6, 2, and 2 hospitals, respectively. The day of second-look endoscopy varied among hospitals. There was no statistical relationship between the postoperative bleeding rate and the differences in these three parameters. Conclusions: Post-ESD management (duration of PPI use, resumption of food intake, and performance of second-look endoscopy) varied among the medical centers; thus, randomized controlled trials are required for an optimal strategy after gastric ESD.

AB - Background and Aims: Bleeding is a major complication after gastric endoscopic submucosal dissection (ESD). An evidence-based strategy for postoperative care related to delayed bleeding is required. We conducted a multicenter survey to assess the current status of management after gastric ESD. Methods: A total of 1,814 gastric epithelial neoplasms in 2009 at ten tertiary referral centers were enrolled. The current status of the management after gastric ESD (use of an antisecretory drug, food intake, and second-look endoscopy) at participating hospitals was assessed. Furthermore, the rate of post-ESD bleeding and the differences in each parameter were retrospectively analyzed. Results: Postoperative bleeding occurred in 100 cases (5.5%), which included 62 cases of bleeding within 24 h after ESD. In all of the hospitals, proton pump inhibitors (PPIs) were used. The median administration period was 56 days (range 14-60 days). Food intake was resumed from postoperative day (POD) 1 in 4 hospitals and from POD 2 in 6 hospitals. Second-look endoscopy was performed for almost all cases, fewer cases, and rarely or none in 6, 2, and 2 hospitals, respectively. The day of second-look endoscopy varied among hospitals. There was no statistical relationship between the postoperative bleeding rate and the differences in these three parameters. Conclusions: Post-ESD management (duration of PPI use, resumption of food intake, and performance of second-look endoscopy) varied among the medical centers; thus, randomized controlled trials are required for an optimal strategy after gastric ESD.

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