A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis

Japan Scoliosis Clinical Research Group (JSCRG)

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis (AIS) is the most common type of scoliosis. Controlling its curve progression is the most important clinical task. Although recent genome-wide association studies (GWASs) identified several susceptibility loci associated with the development of AIS, the etiology of curve progression has been still unknown. Our previous GWAS has identified that rs12946942 showed significant association with severe AIS. To confirm the association, we conducted an international meta-analysis using four cohorts with different ethnicity. We analyzed 2272 severe AIS cases and 13,859 controls in total, and found the replication of significant association of rs12946942 (combined P = 7.23×10 −13 ; odds ratio = 1.36, 95% confidence interval = 1.25−1.49). In silico analyses suggested that SOX9 is the most likely susceptibility gene for AIS curve progression in the locus.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalJournal of Human Genetics
Volume64
Issue number5
DOIs
Publication statusPublished - 2019 May 1

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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