A nation-wide survey of follow-up strategies for esophageal cancer patients after a curative esophagectomy or a complete response by definitive chemoradiotherapy in Japan

Yasushi Toh, Yuukou Kitagawa, Hiroyuki Kuwano, Motoyasu Kusano, Tsuneo Oyama, Manabu Muto, Hiroyuki Kato, Hiroya Takeuchi, Yuichiro Doki, Yoshio Naomoto, Kenji Nemoto, Hisahiro Matsubara, Tatsuya Miyazaki, Akio Yanagisawa, Takashi Uno, Ken Kato, Masahiro Yoshida, Hirofumi Kawakubo, Eisuke Booka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There is a lack of critical evidence to justify the methods of follow-up after a curative esophagectomy or a complete response to definitive chemoradiotherapy (dCRT). Consequently, a wide variety of practices are in place throughout the world. Methods: A questionnaire concerning follow-up protocols was sent via electronic email for a nation-wide survey of the 117 Japanese hospitals that are recognized by the Japan Esophageal Society as training facilities for certified esophageal surgeons. Seventy-seven hospitals responded to the questionnaire. Results: Most hospitals follow their patients for at least 5 years after esophagectomy or dCRT, usually at a frequency of more than 4 times per year with clinical visits and physical examinations in the 1st and 2nd year after treatment. About 65–75 and 40 % of the hospitals continue the follow-up until the 7th and 10th year after treatment, respectively. Most hospitals measure CEA and SCC-Ag and almost all hospitals utilize CT scans of the cervix, chest and abdomen for the follow-up. Most of the hospitals reported performing an upper gastrointestinal endoscopy at least once per year until the 5th year after treatment, more frequently for post-dCRT patients than for post-esophagectomy patients. Other imaging modalities such as FDG-PET/CT, cervical and abdominal USs, and chest and abdominal X-rays were incorporated at much lower rates. Conclusions: Follow-up protocols for patients who have been treated for esophageal cancer with curative intent vary among the hospitals in Japan. Based on these data, the most popular follow-up protocols in Japan are shown.

Original languageEnglish
JournalEsophagus
DOIs
Publication statusAccepted/In press - 2015 Oct 13

Fingerprint

Esophagectomy
Chemoradiotherapy
Esophageal Neoplasms
Japan
Thorax
Gastrointestinal Endoscopy
Surveys and Questionnaires
Cervix Uteri
Abdomen
Physical Examination
Therapeutics
X-Rays

Keywords

  • Curative esophagectomy
  • Definitive chemoradiation
  • Esophageal cancer
  • Follow-up strategies
  • Nation-wide survey
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A nation-wide survey of follow-up strategies for esophageal cancer patients after a curative esophagectomy or a complete response by definitive chemoradiotherapy in Japan. / Toh, Yasushi; Kitagawa, Yuukou; Kuwano, Hiroyuki; Kusano, Motoyasu; Oyama, Tsuneo; Muto, Manabu; Kato, Hiroyuki; Takeuchi, Hiroya; Doki, Yuichiro; Naomoto, Yoshio; Nemoto, Kenji; Matsubara, Hisahiro; Miyazaki, Tatsuya; Yanagisawa, Akio; Uno, Takashi; Kato, Ken; Yoshida, Masahiro; Kawakubo, Hirofumi; Booka, Eisuke.

In: Esophagus, 13.10.2015.

Research output: Contribution to journalArticle

Toh, Y, Kitagawa, Y, Kuwano, H, Kusano, M, Oyama, T, Muto, M, Kato, H, Takeuchi, H, Doki, Y, Naomoto, Y, Nemoto, K, Matsubara, H, Miyazaki, T, Yanagisawa, A, Uno, T, Kato, K, Yoshida, M, Kawakubo, H & Booka, E 2015, 'A nation-wide survey of follow-up strategies for esophageal cancer patients after a curative esophagectomy or a complete response by definitive chemoradiotherapy in Japan', Esophagus. https://doi.org/10.1007/s10388-015-0511-7
Toh, Yasushi ; Kitagawa, Yuukou ; Kuwano, Hiroyuki ; Kusano, Motoyasu ; Oyama, Tsuneo ; Muto, Manabu ; Kato, Hiroyuki ; Takeuchi, Hiroya ; Doki, Yuichiro ; Naomoto, Yoshio ; Nemoto, Kenji ; Matsubara, Hisahiro ; Miyazaki, Tatsuya ; Yanagisawa, Akio ; Uno, Takashi ; Kato, Ken ; Yoshida, Masahiro ; Kawakubo, Hirofumi ; Booka, Eisuke. / A nation-wide survey of follow-up strategies for esophageal cancer patients after a curative esophagectomy or a complete response by definitive chemoradiotherapy in Japan. In: Esophagus. 2015.
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abstract = "Background: There is a lack of critical evidence to justify the methods of follow-up after a curative esophagectomy or a complete response to definitive chemoradiotherapy (dCRT). Consequently, a wide variety of practices are in place throughout the world. Methods: A questionnaire concerning follow-up protocols was sent via electronic email for a nation-wide survey of the 117 Japanese hospitals that are recognized by the Japan Esophageal Society as training facilities for certified esophageal surgeons. Seventy-seven hospitals responded to the questionnaire. Results: Most hospitals follow their patients for at least 5 years after esophagectomy or dCRT, usually at a frequency of more than 4 times per year with clinical visits and physical examinations in the 1st and 2nd year after treatment. About 65–75 and 40 {\%} of the hospitals continue the follow-up until the 7th and 10th year after treatment, respectively. Most hospitals measure CEA and SCC-Ag and almost all hospitals utilize CT scans of the cervix, chest and abdomen for the follow-up. Most of the hospitals reported performing an upper gastrointestinal endoscopy at least once per year until the 5th year after treatment, more frequently for post-dCRT patients than for post-esophagectomy patients. Other imaging modalities such as FDG-PET/CT, cervical and abdominal USs, and chest and abdominal X-rays were incorporated at much lower rates. Conclusions: Follow-up protocols for patients who have been treated for esophageal cancer with curative intent vary among the hospitals in Japan. Based on these data, the most popular follow-up protocols in Japan are shown.",
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AU - Toh, Yasushi

AU - Kitagawa, Yuukou

AU - Kuwano, Hiroyuki

AU - Kusano, Motoyasu

AU - Oyama, Tsuneo

AU - Muto, Manabu

AU - Kato, Hiroyuki

AU - Takeuchi, Hiroya

AU - Doki, Yuichiro

AU - Naomoto, Yoshio

AU - Nemoto, Kenji

AU - Matsubara, Hisahiro

AU - Miyazaki, Tatsuya

AU - Yanagisawa, Akio

AU - Uno, Takashi

AU - Kato, Ken

AU - Yoshida, Masahiro

AU - Kawakubo, Hirofumi

AU - Booka, Eisuke

PY - 2015/10/13

Y1 - 2015/10/13

N2 - Background: There is a lack of critical evidence to justify the methods of follow-up after a curative esophagectomy or a complete response to definitive chemoradiotherapy (dCRT). Consequently, a wide variety of practices are in place throughout the world. Methods: A questionnaire concerning follow-up protocols was sent via electronic email for a nation-wide survey of the 117 Japanese hospitals that are recognized by the Japan Esophageal Society as training facilities for certified esophageal surgeons. Seventy-seven hospitals responded to the questionnaire. Results: Most hospitals follow their patients for at least 5 years after esophagectomy or dCRT, usually at a frequency of more than 4 times per year with clinical visits and physical examinations in the 1st and 2nd year after treatment. About 65–75 and 40 % of the hospitals continue the follow-up until the 7th and 10th year after treatment, respectively. Most hospitals measure CEA and SCC-Ag and almost all hospitals utilize CT scans of the cervix, chest and abdomen for the follow-up. Most of the hospitals reported performing an upper gastrointestinal endoscopy at least once per year until the 5th year after treatment, more frequently for post-dCRT patients than for post-esophagectomy patients. Other imaging modalities such as FDG-PET/CT, cervical and abdominal USs, and chest and abdominal X-rays were incorporated at much lower rates. Conclusions: Follow-up protocols for patients who have been treated for esophageal cancer with curative intent vary among the hospitals in Japan. Based on these data, the most popular follow-up protocols in Japan are shown.

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KW - Definitive chemoradiation

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KW - Follow-up strategies

KW - Nation-wide survey

KW - Recurrence

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