A National Survey of Patients With Intestinal Motility Disorders Who Are Potential Candidates for Intestinal Transplantation in Japan

T. Ueno, M. Wada, K. Hoshino, S. Sakamoto, H. Furukawa, M. Fukuzawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Intestinal motility disorders are a major cause of intestinal failure. Severe cases such as idiopathic pseudo-obstruction represent life-threatening illnessed. Intestinal transplantation is a treatment for severe motility disorders with irreversible intestinal failure. However, the prevalence of severe motility disorders is unknown. We performed a national survey to identify patients with intestinal motility disorders who require an intestinal transplant. The national survey of 302 institutions treating intestinal motility disorders identified 147 patients treated from 2006 to 2011 at 46 institutions. The mean patient age was 12.1 years (range, 0.3–77.5). The mean age of onset was 3.0 years (range, 0.0–68.8). Diagnoses included chronic idiopathic intestinal pseudo-obstruction (n = 96), Hirschsprung disease (n = 29), megacystis microcolon intestinal hypoperistalsis syndrome (n = 18), and other (n = 6). There were 126 survivors and 21 patients who died during the last 5 years. The mortality rate was 14.3%. Eighty-five percent of patients required parenteral nutrition for more than 6 months, which was defined as irreversible intestinal failure. Among surviving patients with irreversible intestinal failure, 8 (9.4 %) developed hepatic failure with jaundice and 27 (31.8%) 2 or more central vein thromboses. In all, at least 35 patients (41%) with irreversible failure due to intestinal motility disorders may be candidates for transplantation. The prevalence of severe intestinal motility disorders was elucidated in Japan. Severe cases should be referred to transplant centers.

Original languageEnglish
Pages (from-to)2029-2031
Number of pages3
JournalTransplantation Proceedings
Volume45
Issue number5
DOIs
Publication statusPublished - 2013 Jun

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'A National Survey of Patients With Intestinal Motility Disorders Who Are Potential Candidates for Intestinal Transplantation in Japan'. Together they form a unique fingerprint.

  • Cite this