A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan.

T. Ueno, M. Wada, K. Hoshino, S. Sakamoto, H. Furukawa, M. Fukuzawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Intestinal motility disorders are a major cause of intestinal failure. Severe cases such as idiopathic pseudo-obstruction represent life-threatening illnessed. Intestinal transplantation is a treatment for severe motility disorders with irreversible intestinal failure. However, the prevalence of severe motility disorders is unknown. We performed a national survey to identify patients with intestinal motility disorders who require an intestinal transplant. The national survey of 302 institutions treating intestinal motility disorders identified 147 patients treated from 2006 to 2011 at 46 institutions. The mean patient age was 12.1 years (range, 0.3-77.5). The mean age of onset was 3.0 years (range, 0.0-68.8). Diagnoses included chronic idiopathic intestinal pseudo-obstruction (n = 96), Hirschsprung disease (n = 29), megacystis microcolon intestinal hypoperistalsis syndrome (n = 18), and other (n = 6). There were 126 survivors and 21 patients who died during the last 5 years. The mortality rate was 14.3%. Eighty-five percent of patients required parenteral nutrition for more than 6 months, which was defined as irreversible intestinal failure. Among surviving patients with irreversible intestinal failure, 8 (9.4 %) developed hepatic failure with jaundice and 27 (31.8%) 2 or more central vein thromboses. In all, at least 35 patients (41%) with irreversible failure due to intestinal motility disorders may be candidates for transplantation. The prevalence of severe intestinal motility disorders was elucidated in Japan. Severe cases should be referred to transplant centers.

Original languageEnglish
Pages (from-to)2029-2031
Number of pages3
JournalTransplantation Proceedings
Volume45
Issue number5
Publication statusPublished - 2013 Jun

Fingerprint

Gastrointestinal Motility
Japan
Transplantation
Intestinal Pseudo-Obstruction
Transplants
Hirschsprung Disease
Parenteral Nutrition
Liver Failure
Jaundice
Surveys and Questionnaires
Age of Onset
Survivors
Veins
Thrombosis
Mortality

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan. / Ueno, T.; Wada, M.; Hoshino, K.; Sakamoto, S.; Furukawa, H.; Fukuzawa, M.

In: Transplantation Proceedings, Vol. 45, No. 5, 06.2013, p. 2029-2031.

Research output: Contribution to journalArticle

Ueno, T, Wada, M, Hoshino, K, Sakamoto, S, Furukawa, H & Fukuzawa, M 2013, 'A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan.', Transplantation Proceedings, vol. 45, no. 5, pp. 2029-2031.
Ueno, T. ; Wada, M. ; Hoshino, K. ; Sakamoto, S. ; Furukawa, H. ; Fukuzawa, M. / A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 5. pp. 2029-2031.
@article{12c0335de1bb4e31be35d221f981b2d1,
title = "A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan.",
abstract = "Intestinal motility disorders are a major cause of intestinal failure. Severe cases such as idiopathic pseudo-obstruction represent life-threatening illnessed. Intestinal transplantation is a treatment for severe motility disorders with irreversible intestinal failure. However, the prevalence of severe motility disorders is unknown. We performed a national survey to identify patients with intestinal motility disorders who require an intestinal transplant. The national survey of 302 institutions treating intestinal motility disorders identified 147 patients treated from 2006 to 2011 at 46 institutions. The mean patient age was 12.1 years (range, 0.3-77.5). The mean age of onset was 3.0 years (range, 0.0-68.8). Diagnoses included chronic idiopathic intestinal pseudo-obstruction (n = 96), Hirschsprung disease (n = 29), megacystis microcolon intestinal hypoperistalsis syndrome (n = 18), and other (n = 6). There were 126 survivors and 21 patients who died during the last 5 years. The mortality rate was 14.3{\%}. Eighty-five percent of patients required parenteral nutrition for more than 6 months, which was defined as irreversible intestinal failure. Among surviving patients with irreversible intestinal failure, 8 (9.4 {\%}) developed hepatic failure with jaundice and 27 (31.8{\%}) 2 or more central vein thromboses. In all, at least 35 patients (41{\%}) with irreversible failure due to intestinal motility disorders may be candidates for transplantation. The prevalence of severe intestinal motility disorders was elucidated in Japan. Severe cases should be referred to transplant centers.",
author = "T. Ueno and M. Wada and K. Hoshino and S. Sakamoto and H. Furukawa and M. Fukuzawa",
year = "2013",
month = "6",
language = "English",
volume = "45",
pages = "2029--2031",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - A national survey of patients with intestinal motility disorders who are potential candidates for intestinal transplantation in Japan.

AU - Ueno, T.

AU - Wada, M.

AU - Hoshino, K.

AU - Sakamoto, S.

AU - Furukawa, H.

AU - Fukuzawa, M.

PY - 2013/6

Y1 - 2013/6

N2 - Intestinal motility disorders are a major cause of intestinal failure. Severe cases such as idiopathic pseudo-obstruction represent life-threatening illnessed. Intestinal transplantation is a treatment for severe motility disorders with irreversible intestinal failure. However, the prevalence of severe motility disorders is unknown. We performed a national survey to identify patients with intestinal motility disorders who require an intestinal transplant. The national survey of 302 institutions treating intestinal motility disorders identified 147 patients treated from 2006 to 2011 at 46 institutions. The mean patient age was 12.1 years (range, 0.3-77.5). The mean age of onset was 3.0 years (range, 0.0-68.8). Diagnoses included chronic idiopathic intestinal pseudo-obstruction (n = 96), Hirschsprung disease (n = 29), megacystis microcolon intestinal hypoperistalsis syndrome (n = 18), and other (n = 6). There were 126 survivors and 21 patients who died during the last 5 years. The mortality rate was 14.3%. Eighty-five percent of patients required parenteral nutrition for more than 6 months, which was defined as irreversible intestinal failure. Among surviving patients with irreversible intestinal failure, 8 (9.4 %) developed hepatic failure with jaundice and 27 (31.8%) 2 or more central vein thromboses. In all, at least 35 patients (41%) with irreversible failure due to intestinal motility disorders may be candidates for transplantation. The prevalence of severe intestinal motility disorders was elucidated in Japan. Severe cases should be referred to transplant centers.

AB - Intestinal motility disorders are a major cause of intestinal failure. Severe cases such as idiopathic pseudo-obstruction represent life-threatening illnessed. Intestinal transplantation is a treatment for severe motility disorders with irreversible intestinal failure. However, the prevalence of severe motility disorders is unknown. We performed a national survey to identify patients with intestinal motility disorders who require an intestinal transplant. The national survey of 302 institutions treating intestinal motility disorders identified 147 patients treated from 2006 to 2011 at 46 institutions. The mean patient age was 12.1 years (range, 0.3-77.5). The mean age of onset was 3.0 years (range, 0.0-68.8). Diagnoses included chronic idiopathic intestinal pseudo-obstruction (n = 96), Hirschsprung disease (n = 29), megacystis microcolon intestinal hypoperistalsis syndrome (n = 18), and other (n = 6). There were 126 survivors and 21 patients who died during the last 5 years. The mortality rate was 14.3%. Eighty-five percent of patients required parenteral nutrition for more than 6 months, which was defined as irreversible intestinal failure. Among surviving patients with irreversible intestinal failure, 8 (9.4 %) developed hepatic failure with jaundice and 27 (31.8%) 2 or more central vein thromboses. In all, at least 35 patients (41%) with irreversible failure due to intestinal motility disorders may be candidates for transplantation. The prevalence of severe intestinal motility disorders was elucidated in Japan. Severe cases should be referred to transplant centers.

UR - http://www.scopus.com/inward/record.url?scp=84885647184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885647184&partnerID=8YFLogxK

M3 - Article

C2 - 23769101

AN - SCOPUS:84885647184

VL - 45

SP - 2029

EP - 2031

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 5

ER -