A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

Naoya Fukushima, Kenji Nanao, Hiroyuki Fukushima, Akira Namera, Masaru Miura

Research output: Contribution to journalArticle

Abstract

It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalEuropean Journal of Pediatrics
DOIs
Publication statusAccepted/In press - 2016 Apr 12

Fingerprint

Torsades de Pointes
Tricyclic Antidepressive Agents
Mothers
Clomipramine
Long QT Syndrome
Magnesium Sulfate
Cardiac Arrhythmias
Pregnancy
Pharmaceutical Preparations

Keywords

  • Clomipramine
  • Desmethylclomipramine
  • Placental passage
  • Prolonged QT interval
  • Torsades de Pointes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. / Fukushima, Naoya; Nanao, Kenji; Fukushima, Hiroyuki; Namera, Akira; Miura, Masaru.

In: European Journal of Pediatrics, 12.04.2016, p. 1-4.

Research output: Contribution to journalArticle

Fukushima, Naoya ; Nanao, Kenji ; Fukushima, Hiroyuki ; Namera, Akira ; Miura, Masaru. / A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. In: European Journal of Pediatrics. 2016 ; pp. 1-4.
@article{30e051adaea6434b97b3158dabc462cd,
title = "A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants",
abstract = "It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)",
keywords = "Clomipramine, Desmethylclomipramine, Placental passage, Prolonged QT interval, Torsades de Pointes",
author = "Naoya Fukushima and Kenji Nanao and Hiroyuki Fukushima and Akira Namera and Masaru Miura",
year = "2016",
month = "4",
day = "12",
doi = "10.1007/s00431-016-2722-x",
language = "English",
pages = "1--4",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

AU - Fukushima, Naoya

AU - Nanao, Kenji

AU - Fukushima, Hiroyuki

AU - Namera, Akira

AU - Miura, Masaru

PY - 2016/4/12

Y1 - 2016/4/12

N2 - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

AB - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

KW - Clomipramine

KW - Desmethylclomipramine

KW - Placental passage

KW - Prolonged QT interval

KW - Torsades de Pointes

UR - http://www.scopus.com/inward/record.url?scp=84962808861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962808861&partnerID=8YFLogxK

U2 - 10.1007/s00431-016-2722-x

DO - 10.1007/s00431-016-2722-x

M3 - Article

C2 - 27068648

AN - SCOPUS:84962808861

SP - 1

EP - 4

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

ER -