A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

Naoya Fukushima; Kenji Nanao; Hiroyuki Fukushima; Akira Namera; Masaru Miura

doi:10.1007/s00431-016-2722-x

A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

Naoya Fukushima, Kenji Nanao, Hiroyuki Fukushima, Akira Namera, Masaru Miura

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	European Journal of Pediatrics
DOIs	https://doi.org/10.1007/s00431-016-2722-x
Publication status	Accepted/In press - 2016 Apr 12

Keywords

Clomipramine
Desmethylclomipramine
Placental passage
Prolonged QT interval
Torsades de Pointes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1007/s00431-016-2722-x

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abstract = "It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)",

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AU - Fukushima, Naoya

AU - Nanao, Kenji

AU - Fukushima, Hiroyuki

AU - Namera, Akira

AU - Miura, Masaru

PY - 2016/4/12

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AB - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

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