Abstract
It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | European Journal of Pediatrics |
| DOIs | |
| Publication status | Accepted/In press - 2016 Apr 12 |
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Keywords
- Clomipramine
- Desmethylclomipramine
- Placental passage
- Prolonged QT interval
- Torsades de Pointes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. / Fukushima, Naoya; Nanao, Kenji; Fukushima, Hiroyuki; Namera, Akira; Miura, Masaru.
In: European Journal of Pediatrics, 12.04.2016, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants
AU - Fukushima, Naoya
AU - Nanao, Kenji
AU - Fukushima, Hiroyuki
AU - Namera, Akira
AU - Miura, Masaru
PY - 2016/4/12
Y1 - 2016/4/12
N2 - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)
AB - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)
KW - Clomipramine
KW - Desmethylclomipramine
KW - Placental passage
KW - Prolonged QT interval
KW - Torsades de Pointes
UR - http://www.scopus.com/inward/record.url?scp=84962808861&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962808861&partnerID=8YFLogxK
U2 - 10.1007/s00431-016-2722-x
DO - 10.1007/s00431-016-2722-x
M3 - Article
C2 - 27068648
AN - SCOPUS:84962808861
SP - 1
EP - 4
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
ER -