A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

Naoya Fukushima; Kenji Nanao; Hiroyuki Fukushima; Akira Namera; Masaru Miura

doi:10.1007/s00431-016-2722-x

A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

Naoya Fukushima, Kenji Nanao, Hiroyuki Fukushima, Akira Namera, Masaru Miura

Department of Pediatrics

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	European Journal of Pediatrics
DOIs	https://doi.org/10.1007/s00431-016-2722-x
Publication status	Accepted/In press - 2016 Apr 12

Fingerprint

Keywords

Clomipramine
Desmethylclomipramine
Placental passage
Prolonged QT interval
Torsades de Pointes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

Fukushima, N., Nanao, K., Fukushima, H., Namera, A., & Miura, M. (Accepted/In press). A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. European Journal of Pediatrics, 1-4. https://doi.org/10.1007/s00431-016-2722-x

@article{30e051adaea6434b97b3158dabc462cd,

title = "A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants",

abstract = "It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)",

keywords = "Clomipramine, Desmethylclomipramine, Placental passage, Prolonged QT interval, Torsades de Pointes",

author = "Naoya Fukushima and Kenji Nanao and Hiroyuki Fukushima and Akira Namera and Masaru Miura",

year = "2016",

month = apr

day = "12",

doi = "10.1007/s00431-016-2722-x",

language = "English",

pages = "1--4",

journal = "European Journal of Pediatrics",

issn = "0340-6199",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

AU - Fukushima, Naoya

AU - Nanao, Kenji

AU - Fukushima, Hiroyuki

AU - Namera, Akira

AU - Miura, Masaru

PY - 2016/4/12

Y1 - 2016/4/12

N2 - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

AB - It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)

KW - Clomipramine

KW - Desmethylclomipramine

KW - Placental passage

KW - Prolonged QT interval

KW - Torsades de Pointes

UR - http://www.scopus.com/inward/record.url?scp=84962808861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962808861&partnerID=8YFLogxK

U2 - 10.1007/s00431-016-2722-x

DO - 10.1007/s00431-016-2722-x

M3 - Article

C2 - 27068648

AN - SCOPUS:84962808861

SP - 1

EP - 4

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

ER -

Access to Document

10.1007/s00431-016-2722-x