Abstract
It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP. Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.(Table presented.)
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | European Journal of Pediatrics |
| DOIs | |
| Publication status | Accepted/In press - 2016 Apr 12 |
Keywords
- Clomipramine
- Desmethylclomipramine
- Placental passage
- Prolonged QT interval
- Torsades de Pointes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
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Cite this
Fukushima, N., Nanao, K., Fukushima, H., Namera, A., & Miura, M. (Accepted/In press). A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants. European Journal of Pediatrics, 1-4. https://doi.org/10.1007/s00431-016-2722-x