A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor and pleomorphic xanthoastrocytoma - A case report and review of the literature

K. Ishizawa, S. Terao, K. Kobayashi, Kazunari Yoshida, T. Hirose

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor (DNT) and pleomorphic xanthoastrocytoma (PXA) is described. The patient was a 60-year-old male with a long-standing temporal lobe tumor and seizures. After a long, dormant period, the tumor, which had been localized in the left uncus, re-grew rapidly and extended into the subarachnoidal space and brain stem. The post-operative specimens disclosed two distinct components: an intra-cortical, cystic lesion containing mucinous materials and an extra-cortical, nodular lesion involving the leptomeninges. The former contained oligodendroglia-like small, round cells placed along axonal processes, plus mature neurons situated against mucinous materials (DNT-like component, WHO Grade I). The latter contained spindle and/or pleomorphic cells expressing glial fibrillary acidic protein, having bizarre nuclei and atypical mitotic figures. A reticulin network was developed among the tumor cells (PXA-like component, WHO Grade III). This case illustrates an unusual composite brain tumor, combined DNT and PXA.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalClinical Neuropathology
Volume26
Issue number4
Publication statusPublished - 2007 Jul

Fingerprint

Neuroepithelial Neoplasms
Reticulin
Neoplasms
Glial Fibrillary Acidic Protein
Oligodendroglia
Temporal Lobe
Brain Neoplasms
Brain Stem
Seizures
Neurons

Keywords

  • Composite brain tumor
  • Dysembryoplastic neuroepithelial tumor
  • Pleomorphic xanthoastrocytoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

@article{64867f2f8e5b4684aac63b9d6606e2b7,
title = "A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor and pleomorphic xanthoastrocytoma - A case report and review of the literature",
abstract = "A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor (DNT) and pleomorphic xanthoastrocytoma (PXA) is described. The patient was a 60-year-old male with a long-standing temporal lobe tumor and seizures. After a long, dormant period, the tumor, which had been localized in the left uncus, re-grew rapidly and extended into the subarachnoidal space and brain stem. The post-operative specimens disclosed two distinct components: an intra-cortical, cystic lesion containing mucinous materials and an extra-cortical, nodular lesion involving the leptomeninges. The former contained oligodendroglia-like small, round cells placed along axonal processes, plus mature neurons situated against mucinous materials (DNT-like component, WHO Grade I). The latter contained spindle and/or pleomorphic cells expressing glial fibrillary acidic protein, having bizarre nuclei and atypical mitotic figures. A reticulin network was developed among the tumor cells (PXA-like component, WHO Grade III). This case illustrates an unusual composite brain tumor, combined DNT and PXA.",
keywords = "Composite brain tumor, Dysembryoplastic neuroepithelial tumor, Pleomorphic xanthoastrocytoma",
author = "K. Ishizawa and S. Terao and K. Kobayashi and Kazunari Yoshida and T. Hirose",
year = "2007",
month = "7",
language = "English",
volume = "26",
pages = "169--175",
journal = "Clinical Neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "4",

}

TY - JOUR

T1 - A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor and pleomorphic xanthoastrocytoma - A case report and review of the literature

AU - Ishizawa, K.

AU - Terao, S.

AU - Kobayashi, K.

AU - Yoshida, Kazunari

AU - Hirose, T.

PY - 2007/7

Y1 - 2007/7

N2 - A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor (DNT) and pleomorphic xanthoastrocytoma (PXA) is described. The patient was a 60-year-old male with a long-standing temporal lobe tumor and seizures. After a long, dormant period, the tumor, which had been localized in the left uncus, re-grew rapidly and extended into the subarachnoidal space and brain stem. The post-operative specimens disclosed two distinct components: an intra-cortical, cystic lesion containing mucinous materials and an extra-cortical, nodular lesion involving the leptomeninges. The former contained oligodendroglia-like small, round cells placed along axonal processes, plus mature neurons situated against mucinous materials (DNT-like component, WHO Grade I). The latter contained spindle and/or pleomorphic cells expressing glial fibrillary acidic protein, having bizarre nuclei and atypical mitotic figures. A reticulin network was developed among the tumor cells (PXA-like component, WHO Grade III). This case illustrates an unusual composite brain tumor, combined DNT and PXA.

AB - A neuroepithelial tumor showing combined histological features of dysembryoplastic neuroepithelial tumor (DNT) and pleomorphic xanthoastrocytoma (PXA) is described. The patient was a 60-year-old male with a long-standing temporal lobe tumor and seizures. After a long, dormant period, the tumor, which had been localized in the left uncus, re-grew rapidly and extended into the subarachnoidal space and brain stem. The post-operative specimens disclosed two distinct components: an intra-cortical, cystic lesion containing mucinous materials and an extra-cortical, nodular lesion involving the leptomeninges. The former contained oligodendroglia-like small, round cells placed along axonal processes, plus mature neurons situated against mucinous materials (DNT-like component, WHO Grade I). The latter contained spindle and/or pleomorphic cells expressing glial fibrillary acidic protein, having bizarre nuclei and atypical mitotic figures. A reticulin network was developed among the tumor cells (PXA-like component, WHO Grade III). This case illustrates an unusual composite brain tumor, combined DNT and PXA.

KW - Composite brain tumor

KW - Dysembryoplastic neuroepithelial tumor

KW - Pleomorphic xanthoastrocytoma

UR - http://www.scopus.com/inward/record.url?scp=34347393518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347393518&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 169

EP - 175

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 4

ER -