A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Yasuo Ikeda, Makoto Handa, Mitsuru Murata, Shinya Goto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalHaemostasis
Volume30
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 2000

Keywords

  • Aggregation
  • Platelet adhesion
  • Quartz crystal microbalance
  • Shear stress
  • von Willebrand factor

ASJC Scopus subject areas

  • Hematology

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