A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Yasuo Ikeda; Makoto Handa; Mitsuru Murata; Shinya Goto

doi:10.1159/000054196

A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Yasuo Ikeda, Makoto Handa, Mitsuru Murata, Shinya Goto

Department of Transfusion Medicine and Cell Therapy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

Original language	English
Pages (from-to)	44-52
Number of pages	9
Journal	Haemostasis
Volume	30
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1159/000054196
Publication status	Published - 2000

Keywords

Aggregation
Platelet adhesion
Quartz crystal microbalance
Shear stress
von Willebrand factor

ASJC Scopus subject areas

Hematology

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abstract = "Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.",

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AU - Handa, Makoto

AU - Murata, Mitsuru

AU - Goto, Shinya

PY - 2000

Y1 - 2000

N2 - Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

AB - Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.

KW - Aggregation

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KW - Quartz crystal microbalance

KW - Shear stress

KW - von Willebrand factor

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A new approach to antiplatelet therapy: Inhibitor of GPIb/V/IX-vWF interaction

Abstract

Keywords

ASJC Scopus subject areas

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