Abstract
Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial thrombosis has been proposed by intervening in the interaction between vWF and platelet.
Original language | English |
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Pages (from-to) | 44-52 |
Number of pages | 9 |
Journal | Haemostasis |
Volume | 30 |
Issue number | SUPPL. 3 |
DOIs | |
Publication status | Published - 2000 |
Externally published | Yes |
Keywords
- Aggregation
- Platelet adhesion
- Quartz crystal microbalance
- Shear stress
- von Willebrand factor
ASJC Scopus subject areas
- Hematology