TY - JOUR
T1 - A New Class of DNA‐Cleaving Molecules
T2 - pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones
AU - Nicolaou, K. C.
AU - Skokotas, G.
AU - Maligres, P.
AU - Zuccarello, G.
AU - Schweiger, E. J.
AU - Toshima, K.
AU - Wendeborn, S.
PY - 1989/9
Y1 - 1989/9
N2 - DNA‐cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH‐dependent reaction with maximal activity at pH 8.5. (Figure Presented.)
AB - DNA‐cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH‐dependent reaction with maximal activity at pH 8.5. (Figure Presented.)
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U2 - 10.1002/anie.198912721
DO - 10.1002/anie.198912721
M3 - Article
AN - SCOPUS:0024431409
SN - 1433-7851
VL - 28
SP - 1272
EP - 1275
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 9
ER -