A New Class of DNA‐Cleaving Molecules: pH‐Dependent DNA Cleavage by Propargylic and Allenic Sulfones

K. C. Nicolaou, G. Skokotas, P. Maligres, G. Zuccarello, E. J. Schweiger, K. Toshima, S. Wendeborn

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Abstract

DNA‐cleaving agents are of considerable interest in molecular biology and pharmaceutical chemistry. The Garrett–Braverman reaction sequence has now been utilized as a basis for developing the title compounds; l–3 are examples. They are capable of cleaving ϕX174 DNA in a pH‐dependent reaction with maximal activity at pH 8.5. (Figure Presented.)

Original languageEnglish
Pages (from-to)1272-1275
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume28
Issue number9
DOIs
Publication statusPublished - 1989 Sep

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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