A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa; Mayuko Misawa; Seiichiro Ogawa; Etsu Tashiro; Masaya Imoto

doi:10.1271/bbb.100693

A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa, Mayuko Misawa, Seiichiro Ogawa, Etsu Tashiro, Masaya Imoto

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

Original language	English
Pages (from-to)	367-369
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	75
Issue number	2
DOIs	https://doi.org/10.1271/bbb.100693
Publication status	Published - 2011
Externally published	Yes

Keywords

Carbasugar library
Glucose uptake inhibitor
Inhibitor screening
Tumor glycolysis

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.100693

Cite this

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abstract = "To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.",

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AU - Kitagawa, Mitsuhiro

AU - Misawa, Mayuko

AU - Ogawa, Seiichiro

AU - Tashiro, Etsu

AU - Imoto, Masaya

N1 - Funding Information: This work was supported by a grant from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2011

Y1 - 2011

N2 - To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

AB - To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

KW - Carbasugar library

KW - Glucose uptake inhibitor

KW - Inhibitor screening

KW - Tumor glycolysis

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A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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