A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa, Mayuko Misawa, Seiichiro Ogawa, Etsu Tashiro, Masaya Imoto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number2
DOIs
Publication statusPublished - 2011 Mar 7

Keywords

  • Carbasugar library
  • Glucose uptake inhibitor
  • Inhibitor screening
  • Tumor glycolysis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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