A new, convenient cell-based screening method for small-molecule glycolytic inhibitors

Mitsuhiro Kitagawa, Mayuko Misawa, Seiichiro Ogawa, Etsu Tashiro, Masaya Imoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume75
Issue number2
DOIs
Publication statusPublished - 2011

Fingerprint

Glycolysis
Screening
Molecules
Carbasugars
Tumors
Neoplasms
Cells
Glucose

Keywords

  • Carbasugar library
  • Glucose uptake inhibitor
  • Inhibitor screening
  • Tumor glycolysis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

A new, convenient cell-based screening method for small-molecule glycolytic inhibitors. / Kitagawa, Mitsuhiro; Misawa, Mayuko; Ogawa, Seiichiro; Tashiro, Etsu; Imoto, Masaya.

In: Bioscience, Biotechnology and Biochemistry, Vol. 75, No. 2, 2011, p. 367-369.

Research output: Contribution to journalArticle

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