A new formula for predicting liver metastasis in patients with colorectal cancer: Immunohistochemical analysis of a large series of 439 surgically resected cases

Hiroki Ochiai, Yukihiro Nakanishi, Yuri Fukasawa, Yasunori Sato, Kimio Yoshimura, Yoshihiro Moriya, Yae Kanai, Masahiko Watanabe, Hirotoshi Hasegawa, Yuko Kitagawa, Masaki Kitajima, Setsuo Hirohashi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Objective: The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC). Methods: Nine previously reported predictive markers for liver metastasis and/or prognosis (COX-2, dysadherin, E-cadherin, β-catenin, Ki-67, p53, laminin5γ2, matrilysin and MUC-1) were immunohistochemically investigated in 439 consecutive patients with CRC. We tried to determine the combination of molecules which best predicted liver metastasis. A formula for predicting liver metastasis was constructed using a training cohort comprising 150 cases, and applied to a validation cohort comprising 190 cases and another comprising 99 cases from an outside hospital. Results: A combination of dysadherin, E-cadherin and matrilysin was identified to be best for predicting liver metastasis (area under the curve value, 0.807). The predictive formula: 3× dysadherin score [0 for low expression (≤50% of tumor cells positive) or 1 for high expression (>50%)] + 4× E-cadherin score [0 for preserved (>80% of tumor cells positive) or 1 for reduced (≤80%)] + 2× matrilysin score [0 for low expression (≤30% of tumor cells positive) or 1 for high expression (>30%)] was able to discriminate patients with liver metastasis in the training cohort with a sensitivity of 85.7% and a specificity of 58.9%. The discriminative capacity of the formula was validated in the first cohort with a sensitivity of 87.0% and a specificity of 66.5%, and in the second cohort with a sensitivity of 80% and a specificity of 60.0%. Conclusions: We have established a formula for predicting liver metastasis in patients with CRC, and confirmed that it has a high sensitivity potentially useful for clinical application.

Original languageEnglish
Pages (from-to)32-41
Number of pages10
JournalOncology
Volume75
Issue number1-2
DOIs
Publication statusPublished - 2008 Sep 1

Keywords

  • Clinicopathological study
  • Colorectal cancer
  • Dysadherin
  • E-cadherin
  • Liver metastasis
  • Matrilysin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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