A new leishmanicidal saponin from Brunfelsia grandiflora

Hiroyuki Fuchino, Setsuko Sekita, Kanami Mori, Nobuo Kawahara, Motoyoshi Satake, Fumiyuki Kiuchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Keywords

  • Brunfelsia grandiflora
  • Chiricsanango
  • Furostan
  • Leishmania
  • Solanaceae

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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