A new leishmanicidal saponin from Brunfelsia grandiflora

Hiroyuki Fuchino, Setsuko Sekita, Kanami Mori, Nobuo Kawahara, Motoyoshi Satake, Fumiyuki Kiuchi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O- β-D-glucopyranosyl 22 α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)} -β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number1
DOIs
Publication statusPublished - 2008 Jan
Externally publishedYes

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Leishmania major
Spectroscopic analysis
Saponins
Chemical reactions
In Vitro Techniques

Keywords

  • Brunfelsia grandiflora
  • Chiricsanango
  • Furostan
  • Leishmania
  • Solanaceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

A new leishmanicidal saponin from Brunfelsia grandiflora. / Fuchino, Hiroyuki; Sekita, Setsuko; Mori, Kanami; Kawahara, Nobuo; Satake, Motoyoshi; Kiuchi, Fumiyuki.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 1, 01.2008, p. 93-96.

Research output: Contribution to journalArticle

Fuchino, H, Sekita, S, Mori, K, Kawahara, N, Satake, M & Kiuchi, F 2008, 'A new leishmanicidal saponin from Brunfelsia grandiflora', Chemical and Pharmaceutical Bulletin, vol. 56, no. 1, pp. 93-96. https://doi.org/10.1248/cpb.56.93
Fuchino, Hiroyuki ; Sekita, Setsuko ; Mori, Kanami ; Kawahara, Nobuo ; Satake, Motoyoshi ; Kiuchi, Fumiyuki. / A new leishmanicidal saponin from Brunfelsia grandiflora. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 1. pp. 93-96.
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