A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa; Megumi Sumino; Tomonori Nakamura; Shingo Yano; Toshikazu Sekine; Nijsiri Ruangrungsi; Kazuko Watanabe; Fumio Ikegami

doi:10.1248/cpb.52.1265

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuko Watanabe, Fumio Ikegami

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

Original language	English
Pages (from-to)	1265-1267
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	10
DOIs	https://doi.org/10.1248/cpb.52.1265
Publication status	Published - 2004 Oct 1
Externally published	Yes

Keywords

Anti-inflammatory effect
Balanophora abbreviata
Balanophoraceae
Inducible nitric oxide synthase (iNOS)
Lignan

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Hosokawa, A., Sumino, M., Nakamura, T., Yano, S., Sekine, T., Ruangrungsi, N., Watanabe, K., & Ikegami, F. (2004). A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. Chemical and Pharmaceutical Bulletin, 52(10), 1265-1267. https://doi.org/10.1248/cpb.52.1265

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. / Hosokawa, Akihiro; Sumino, Megumi; Nakamura, Tomonori; Yano, Shingo; Sekine, Toshikazu; Ruangrungsi, Nijsiri; Watanabe, Kazuko; Ikegami, Fumio.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 10, 01.10.2004, p. 1265-1267.

Research output: Contribution to journal › Article

Hosokawa, Akihiro ; Sumino, Megumi ; Nakamura, Tomonori ; Yano, Shingo ; Sekine, Toshikazu ; Ruangrungsi, Nijsiri ; Watanabe, Kazuko ; Ikegami, Fumio. / A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 10. pp. 1265-1267.

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