A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuko Watanabe, Fumio Ikegami

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

Original languageEnglish
Pages (from-to)1265-1267
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number10
DOIs
Publication statusPublished - 2004 Oct
Externally publishedYes

Fingerprint

Lignans
Nitric Oxide Synthase Type II
Lipopolysaccharides
Balanophoraceae
Nuclear magnetic resonance

Keywords

  • Anti-inflammatory effect
  • Balanophora abbreviata
  • Balanophoraceae
  • Inducible nitric oxide synthase (iNOS)
  • Lignan

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. / Hosokawa, Akihiro; Sumino, Megumi; Nakamura, Tomonori; Yano, Shingo; Sekine, Toshikazu; Ruangrungsi, Nijsiri; Watanabe, Kazuko; Ikegami, Fumio.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 10, 10.2004, p. 1265-1267.

Research output: Contribution to journalArticle

Hosokawa, Akihiro ; Sumino, Megumi ; Nakamura, Tomonori ; Yano, Shingo ; Sekine, Toshikazu ; Ruangrungsi, Nijsiri ; Watanabe, Kazuko ; Ikegami, Fumio. / A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 10. pp. 1265-1267.
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