A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuko Watanabe, Fumio Ikegami

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Abstract

Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

Original languageEnglish
Pages (from-to)1265-1267
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number10
DOIs
Publication statusPublished - 2004 Oct 1
Externally publishedYes

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Keywords

  • Anti-inflammatory effect
  • Balanophora abbreviata
  • Balanophoraceae
  • Inducible nitric oxide synthase (iNOS)
  • Lignan

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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