A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa; Megumi Sumino; Tomonori Nakamura; Shingo Yano; Toshikazu Sekine; Nijsiri Ruangrungsi; Kazuko Watanabe; Fumio Ikegami

doi:10.1248/cpb.52.1265

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuko Watanabe, Fumio Ikegami

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

Original language	English
Pages (from-to)	1265-1267
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	10
DOIs	https://doi.org/10.1248/cpb.52.1265
Publication status	Published - 2004 Oct
Externally published	Yes

Keywords

Anti-inflammatory effect
Balanophora abbreviata
Balanophoraceae
Inducible nitric oxide synthase (iNOS)
Lignan

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.52.1265

Cite this

@article{70e51e7d5bc24fd19ddcd673f005648d,

title = "A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression",

abstract = "Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.",

keywords = "Anti-inflammatory effect, Balanophora abbreviata, Balanophoraceae, Inducible nitric oxide synthase (iNOS), Lignan",

author = "Akihiro Hosokawa and Megumi Sumino and Tomonori Nakamura and Shingo Yano and Toshikazu Sekine and Nijsiri Ruangrungsi and Kazuko Watanabe and Fumio Ikegami",

year = "2004",

month = oct,

doi = "10.1248/cpb.52.1265",

language = "English",

volume = "52",

pages = "1265--1267",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "10",

}

TY - JOUR

T1 - A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

AU - Hosokawa, Akihiro

AU - Sumino, Megumi

AU - Nakamura, Tomonori

AU - Yano, Shingo

AU - Sekine, Toshikazu

AU - Ruangrungsi, Nijsiri

AU - Watanabe, Kazuko

AU - Ikegami, Fumio

PY - 2004/10

Y1 - 2004/10

N2 - Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

AB - Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

KW - Anti-inflammatory effect

KW - Balanophora abbreviata

KW - Balanophoraceae

KW - Inducible nitric oxide synthase (iNOS)

KW - Lignan

UR - http://www.scopus.com/inward/record.url?scp=16644398984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16644398984&partnerID=8YFLogxK

U2 - 10.1248/cpb.52.1265

DO - 10.1248/cpb.52.1265

M3 - Article

C2 - 15467252

AN - SCOPUS:16644398984

VL - 52

SP - 1265

EP - 1267

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 10

ER -

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this