A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa; Megumi Sumino; Tomonori Nakamura; Shingo Yano; Toshikazu Sekine; Nijsiri Ruangrungsi; Kazuko Watanabe; Fumio Ikegami

doi:10.1248/cpb.52.1265

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression

Akihiro Hosokawa, Megumi Sumino, Tomonori Nakamura, Shingo Yano, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuko Watanabe, Fumio Ikegami

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

Six lignans including a new lignan (1), β-sitosterol glucopyranoside and phenylpropanoids were isolated from the whole plants of Balanophora abbreviata Bl. (Balanophoraceae). Their structures were determined by NMR, MS analysis and other spectroscopic methods. Lignans (1, 2 and 4) showed potent inhibitory activities on the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells.

Original language	English
Pages (from-to)	1265-1267
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	10
DOIs	https://doi.org/10.1248/cpb.52.1265
Publication status	Published - 2004 Oct 1
Externally published	Yes

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Keywords

Anti-inflammatory effect
Balanophora abbreviata
Balanophoraceae
Inducible nitric oxide synthase (iNOS)
Lignan

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Cite this

Hosokawa, A., Sumino, M., Nakamura, T., Yano, S., Sekine, T., Ruangrungsi, N., Watanabe, K., & Ikegami, F. (2004). A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. Chemical and Pharmaceutical Bulletin, 52(10), 1265-1267. https://doi.org/10.1248/cpb.52.1265

A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. / Hosokawa, Akihiro; Sumino, Megumi; Nakamura, Tomonori; Yano, Shingo; Sekine, Toshikazu; Ruangrungsi, Nijsiri; Watanabe, Kazuko; Ikegami, Fumio.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 10, 01.10.2004, p. 1265-1267.

Research output: Contribution to journal › Article

Hosokawa, Akihiro ; Sumino, Megumi ; Nakamura, Tomonori ; Yano, Shingo ; Sekine, Toshikazu ; Ruangrungsi, Nijsiri ; Watanabe, Kazuko ; Ikegami, Fumio. / A new lignan from Balanophora abbreviata and inhibition of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 10. pp. 1265-1267.

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10.1248/cpb.52.1265