A New Mutant Strain of Gunn-LA Wistar Rats with Genetic Deficiencies in Bilirubin and Androsterone Uridine Diphosphate-Glucuronosyltransferases

Fusako Nagai, Hiroshi Homma, Michio Matsui

Research output: Contribution to journalArticle

Abstract

Hooded Gunn rats which have low-activity of 4-nitrophenol uridine diphosphateglucuronosyltransferase (GT) and defect in bilirubin GT were crossed with albino LA Wistar rats with a defect in androsterone GT. From F2 and F3 progeny were selected Gunn-LA Wistar rats which have defective bilirubin and androsterone GTs and low-active 4-nitrophenol GT. These rats had either hooded or albino coat color. In order to establish a uniform genetic background, albino male Gunn-LA Wistar rats were crossed with heterozygous albino female Gunn-LA Wistar rats in terms of bilirubin GT. The offsprings were all albino and were classified to Gunn-LA Wistar rats and heterozygous Gunn-LA Wistar rats by assaying their hepatic GT activities or by the appearance of jaundice. The linkage relationships between GT and coat color genes are discussed.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalJournal of Pharmacobio-Dynamics
Volume12
Issue number5
DOIs
Publication statusPublished - 1989 Dec

Keywords

  • 4-nitrophenol
  • Gunn-LA Wistar rat
  • androsterone
  • bilirubin
  • coat color
  • genetic linkage
  • isoenzyme deficiency
  • uridine diphosphate-glucuronosyltransferase

ASJC Scopus subject areas

  • Pharmacology

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