A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ

Tsuyoshi Saitoh, Chika Shimada, Masatoshi Takeiri, Mitsuhiro Shiino, Shigeru Ohba, Rika Obata, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.

Original languageEnglish
Pages (from-to)5638-5642
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number19
DOIs
Publication statusPublished - 2010 Oct 1

Keywords

  • DHMEQ
  • Epoxyquinol derivatives
  • NF-κB inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Saitoh, T., Shimada, C., Takeiri, M., Shiino, M., Ohba, S., Obata, R., Ishikawa, Y., Umezawa, K., & Nishiyama, S. (2010). A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. Bioorganic and Medicinal Chemistry Letters, 20(19), 5638-5642. https://doi.org/10.1016/j.bmcl.2010.08.036