A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ

Tsuyoshi Saitoh, Chika Shimada, Masatoshi Takeiri, Mitsuhiro Shiino, Shigeru Ohba, Rika Obata, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The amino-epoxyquinols 6a and 6b were synthesized as soluble derivatives of an NF-κB inhibitor DHMEQ (1). In spite of the opposite configuration from 1, 6b rather than 6a affected the deactivation of NF-κB, based on NO secretion and MALDI-TOF MS analysis. It was indicated that 6b inhibited the activation by different manner from that of 1.

Original languageEnglish
Pages (from-to)5638-5642
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number19
DOIs
Publication statusPublished - 2010 Oct 1

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Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Chemical activation
Derivatives

Keywords

  • DHMEQ
  • Epoxyquinol derivatives
  • NF-κB inhibitor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Saitoh, T., Shimada, C., Takeiri, M., Shiino, M., Ohba, S., Obata, R., ... Nishiyama, S. (2010). A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. Bioorganic and Medicinal Chemistry Letters, 20(19), 5638-5642. https://doi.org/10.1016/j.bmcl.2010.08.036

A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. / Saitoh, Tsuyoshi; Shimada, Chika; Takeiri, Masatoshi; Shiino, Mitsuhiro; Ohba, Shigeru; Obata, Rika; Ishikawa, Yuichi; Umezawa, Kazuo; Nishiyama, Shigeru.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 19, 01.10.2010, p. 5638-5642.

Research output: Contribution to journalArticle

Saitoh, T, Shimada, C, Takeiri, M, Shiino, M, Ohba, S, Obata, R, Ishikawa, Y, Umezawa, K & Nishiyama, S 2010, 'A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 19, pp. 5638-5642. https://doi.org/10.1016/j.bmcl.2010.08.036
Saitoh, Tsuyoshi ; Shimada, Chika ; Takeiri, Masatoshi ; Shiino, Mitsuhiro ; Ohba, Shigeru ; Obata, Rika ; Ishikawa, Yuichi ; Umezawa, Kazuo ; Nishiyama, Shigeru. / A new NF-κB inhibitor based on the amino-epoxyquinol core of DHMEQ. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 19. pp. 5638-5642.
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