A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis

Yoshiyuki Yamagishi, Hidetsugu Saito, Hirotoshi Ebinuma, Masahiro Kikuchi, Keisuke Ojiro, Hideaki Kanamori, Shinichiro Tada, Yoshinori Horie, Shinzo Kato, Toshifumi Hibi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background/Aims: King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess the value of liver volumetry and to generate a new prognostic formula. Methods: Computed tomography-derived liver volume (CTLV) and standardized liver volume (SLV) of 30 adult ALF patients were calculated at the time of diagnosis. Patients were assigned to one of two groups: group A consisted of 13 patients who recovered without surgical intervention, and group B consisted of 17 patients who died due to liver failure or who underwent living donor liver transplantation (LDLT). Results: The median CTLV/SLV ratios of groups A and B were 1.019 and 0.757, respectively (P = 0.0009). The difference was most significant (P = 0.0002) at the probability cutoff point of 0.80 for CTLV/SLV ratio; the sensitivity and specificity were 76.5% and 92.3%, respectively. Serum total bilirubin (TB) levels and CTLV/SLV ratio were selected as independent prognostic factors by multivariate analysis. A prognostic formula including volumetric analysis was established: Z = -2.3813 - [0.15234 × TB (mg/dl)] + [4.5734 × CTLV/SLV] (AUC = 0.87783, P = 0.0002). Conclusions: The CTLV/SLV ratio is a very useful marker for predicting the prognosis of adult ALF. Our prognostic formula including only the CTLV/SLV ratio and TB is simple and useful and awaits validation in a future larger-scale prospective study.

Original languageEnglish
Pages (from-to)615-623
Number of pages9
JournalJournal of Gastroenterology
Volume44
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Acute Liver Failure
Tomography
Liver
Bilirubin
End Stage Liver Disease
Living Donors
Liver Failure
Liver Transplantation

Keywords

  • Computed tomography-derived liver volume/standardized liver volume ratio (CTLV/SLV)
  • King's College Hospital (KCH) criteria
  • Liver atrophy
  • Living donor liver transplantation (LDLT)
  • Model for end-stage liver disease (MELD)

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis. / Yamagishi, Yoshiyuki; Saito, Hidetsugu; Ebinuma, Hirotoshi; Kikuchi, Masahiro; Ojiro, Keisuke; Kanamori, Hideaki; Tada, Shinichiro; Horie, Yoshinori; Kato, Shinzo; Hibi, Toshifumi.

In: Journal of Gastroenterology, Vol. 44, No. 6, 2009, p. 615-623.

Research output: Contribution to journalArticle

Yamagishi, Yoshiyuki ; Saito, Hidetsugu ; Ebinuma, Hirotoshi ; Kikuchi, Masahiro ; Ojiro, Keisuke ; Kanamori, Hideaki ; Tada, Shinichiro ; Horie, Yoshinori ; Kato, Shinzo ; Hibi, Toshifumi. / A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis. In: Journal of Gastroenterology. 2009 ; Vol. 44, No. 6. pp. 615-623.
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abstract = "Background/Aims: King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess the value of liver volumetry and to generate a new prognostic formula. Methods: Computed tomography-derived liver volume (CTLV) and standardized liver volume (SLV) of 30 adult ALF patients were calculated at the time of diagnosis. Patients were assigned to one of two groups: group A consisted of 13 patients who recovered without surgical intervention, and group B consisted of 17 patients who died due to liver failure or who underwent living donor liver transplantation (LDLT). Results: The median CTLV/SLV ratios of groups A and B were 1.019 and 0.757, respectively (P = 0.0009). The difference was most significant (P = 0.0002) at the probability cutoff point of 0.80 for CTLV/SLV ratio; the sensitivity and specificity were 76.5{\%} and 92.3{\%}, respectively. Serum total bilirubin (TB) levels and CTLV/SLV ratio were selected as independent prognostic factors by multivariate analysis. A prognostic formula including volumetric analysis was established: Z = -2.3813 - [0.15234 × TB (mg/dl)] + [4.5734 × CTLV/SLV] (AUC = 0.87783, P = 0.0002). Conclusions: The CTLV/SLV ratio is a very useful marker for predicting the prognosis of adult ALF. Our prognostic formula including only the CTLV/SLV ratio and TB is simple and useful and awaits validation in a future larger-scale prospective study.",
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T1 - A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis

AU - Yamagishi, Yoshiyuki

AU - Saito, Hidetsugu

AU - Ebinuma, Hirotoshi

AU - Kikuchi, Masahiro

AU - Ojiro, Keisuke

AU - Kanamori, Hideaki

AU - Tada, Shinichiro

AU - Horie, Yoshinori

AU - Kato, Shinzo

AU - Hibi, Toshifumi

PY - 2009

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N2 - Background/Aims: King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess the value of liver volumetry and to generate a new prognostic formula. Methods: Computed tomography-derived liver volume (CTLV) and standardized liver volume (SLV) of 30 adult ALF patients were calculated at the time of diagnosis. Patients were assigned to one of two groups: group A consisted of 13 patients who recovered without surgical intervention, and group B consisted of 17 patients who died due to liver failure or who underwent living donor liver transplantation (LDLT). Results: The median CTLV/SLV ratios of groups A and B were 1.019 and 0.757, respectively (P = 0.0009). The difference was most significant (P = 0.0002) at the probability cutoff point of 0.80 for CTLV/SLV ratio; the sensitivity and specificity were 76.5% and 92.3%, respectively. Serum total bilirubin (TB) levels and CTLV/SLV ratio were selected as independent prognostic factors by multivariate analysis. A prognostic formula including volumetric analysis was established: Z = -2.3813 - [0.15234 × TB (mg/dl)] + [4.5734 × CTLV/SLV] (AUC = 0.87783, P = 0.0002). Conclusions: The CTLV/SLV ratio is a very useful marker for predicting the prognosis of adult ALF. Our prognostic formula including only the CTLV/SLV ratio and TB is simple and useful and awaits validation in a future larger-scale prospective study.

AB - Background/Aims: King's College Hospital (KCH) criteria and the model for end-stage liver disease (MELD) score are useful and widely employed prognostic markers for acute liver failure (ALF). We previously reported that liver atrophy is an important prognostic factor for ALF. The aim of the present study was to assess the value of liver volumetry and to generate a new prognostic formula. Methods: Computed tomography-derived liver volume (CTLV) and standardized liver volume (SLV) of 30 adult ALF patients were calculated at the time of diagnosis. Patients were assigned to one of two groups: group A consisted of 13 patients who recovered without surgical intervention, and group B consisted of 17 patients who died due to liver failure or who underwent living donor liver transplantation (LDLT). Results: The median CTLV/SLV ratios of groups A and B were 1.019 and 0.757, respectively (P = 0.0009). The difference was most significant (P = 0.0002) at the probability cutoff point of 0.80 for CTLV/SLV ratio; the sensitivity and specificity were 76.5% and 92.3%, respectively. Serum total bilirubin (TB) levels and CTLV/SLV ratio were selected as independent prognostic factors by multivariate analysis. A prognostic formula including volumetric analysis was established: Z = -2.3813 - [0.15234 × TB (mg/dl)] + [4.5734 × CTLV/SLV] (AUC = 0.87783, P = 0.0002). Conclusions: The CTLV/SLV ratio is a very useful marker for predicting the prognosis of adult ALF. Our prognostic formula including only the CTLV/SLV ratio and TB is simple and useful and awaits validation in a future larger-scale prospective study.

KW - Computed tomography-derived liver volume/standardized liver volume ratio (CTLV/SLV)

KW - King's College Hospital (KCH) criteria

KW - Liver atrophy

KW - Living donor liver transplantation (LDLT)

KW - Model for end-stage liver disease (MELD)

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