A new therapeutic application of brain-machine interface (BMI) training followed by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy for patients with severe hemiparetic stroke: A proof of concept study

Michiyuki Kawakami, Toshiyuki Fujiwara, Junichi Ushiba, Atsuko Nishimoto, Kaoru Abe, Kaoru Honaga, Atsuko Nishimura, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa Masakado, Meigen Liu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy improved paretic upper extremity motor function in patients with severe to moderate hemiparesis. We hypothesized that brain machine interface (BMI) training would be able to increase paretic finger muscle activity enough to apply HANDS therapy in patients with severe hemiparesis, whose finger extensor was absent. Objective: The aim of this study was to assess the efficacy of BMI training followed by HANDS therapy in patients with severe hemiparesis. Methods: Twenty-nine patients with chronic stroke who could not extend their paretic fingers were participated this study. We applied BMI training for 10 days at 40min per day. The BMI detected the patients' motor imagery of paretic finger extension with event-related desynchronization (ERD) over the affected primary sensorimotor cortex, recorded with electroencephalography. Patients wore a motor-driven orthosis, which extended their paretic fingers and was triggered with ERD. When muscle activity in their paretic fingers was detected with surface electrodes after 10 days of BMI training, we applied HANDS therapy for the following 3 weeks. In HANDS therapy, participants received closed-loop, electromyogram-controlled, neuromuscular electrical stimulation (NMES) combined with a wrist-hand splint for 3 weeks at 8 hours a day. Before BMI training, after BMI training, after HANDS therapy and 3month after HANDS therapy, we assessed Fugl-Meyer Assessment upper extremity motor score (FMA) and the Motor Activity Log14-Amount of Use (MAL-AOU) score. Results: After 10 days of BMI training, finger extensor activity had appeared in 21 patients. Eighteen of 21 patients then participated in 3 weeks of HANDS therapy. We found a statistically significant improvement in the FMA and the MAL-AOU scores after the BMI training, and further improvement was seen after the HANDS therapy. Conclusion: Combining BMI training with HANDS therapy could be an effective therapeutic strategy for severe UE paralysis after stroke.

Original languageEnglish
Pages (from-to)789-797
Number of pages9
JournalRestorative Neurology and Neuroscience
Volume34
Issue number5
DOIs
Publication statusPublished - 2016

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Keywords

  • Brain-machine interface
  • rehabilitation
  • stroke
  • upper extremity

ASJC Scopus subject areas

  • Medicine(all)
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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