A non-calorie-restricted low-carbohydrate diet is effective as an alternative therapy for patients with type 2 diabetes

Yoshifumi Yamada, Junichi Uchida, Hisa Izumi, Yoko Tsukamoto, Gaku Inoue, Yuichi Watanabe, Junichiro Irie, Satoru Yamada

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective Although caloric restriction is a widely used intervention to reduce body weight and insulin resistance, many patients are unable to comply with such dietary therapy for long periods. The clinical effectiveness of low-carbohydrate diets was recently described in a position statement of Diabetes UK and a scientific review conducted by the American Diabetes Association. However, randomised trials of dietary interventions in Japanese patients with type 2 diabetes are scarce. Therefore, the aim of this study was to examine the effects of a non-calorie-restricted, low-carbohydrate diet in Japanese patients unable to adhere to a calorie-restricted diet. Methods The enrolled patients were randomly allocated to receive a conventional calorie-restricted diet or low-carbohydrate diet. The patients received consultations every two months from a registered dietician for six months. We compared the effects of the two dietary interventions on glycaemic control and metabolic profiles. Results The HbA1c levels decreased significantly from baseline to six months in the low-carbohydrate diet group (baseline 7.6±0.4%, six months 7.0±0.7%, p=0.03) but not in the calorie-restricted group (baseline 7.7±0.6%, six months 7.5±1.0%, n.s.), (between-group comparison, p=0.03). The patients in the former group also experienced improvements in their triglyceride levels, without experiencing any major adverse effects or a decline in the quality of life. Conclusion Our findings suggest that a low-carbohydrate diet is effective in lowering the HbA1c and tri-glyceride levels in patients with type 2 diabetes who are unable to adhere to a calorie-restricted diet.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalInternal Medicine
Volume53
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

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Carbohydrate-Restricted Diet
Complementary Therapies
Type 2 Diabetes Mellitus
Diet
Glycerides
Caloric Restriction
Metabolome
Nutritionists
Insulin Resistance
Triglycerides
Referral and Consultation
Body Weight
Quality of Life

Keywords

  • Calorie restriction
  • Low-carbohydrate diet
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine

Cite this

A non-calorie-restricted low-carbohydrate diet is effective as an alternative therapy for patients with type 2 diabetes. / Yamada, Yoshifumi; Uchida, Junichi; Izumi, Hisa; Tsukamoto, Yoko; Inoue, Gaku; Watanabe, Yuichi; Irie, Junichiro; Yamada, Satoru.

In: Internal Medicine, Vol. 53, No. 1, 01.01.2014, p. 13-19.

Research output: Contribution to journalArticle

Yamada, Yoshifumi ; Uchida, Junichi ; Izumi, Hisa ; Tsukamoto, Yoko ; Inoue, Gaku ; Watanabe, Yuichi ; Irie, Junichiro ; Yamada, Satoru. / A non-calorie-restricted low-carbohydrate diet is effective as an alternative therapy for patients with type 2 diabetes. In: Internal Medicine. 2014 ; Vol. 53, No. 1. pp. 13-19.
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