A non-invasive portable blood-glucose monitoring system: sampling of suction effusion fluid

T. Arai, S. Kayashima, M. Kikuchi, A. Kaneyoshi, N. Itoh

Research output: Contribution to journalReview article


We developed a new portable transcutaneous blood glucose monitoring system using non-invasive collection of suction effusion fluid (SEF) from human skin. A ion sensitive field effect transistor (ISFET) sensor was employed to measure glucose concentration in a very small quantity of the SEF. The system was composed of a couple of portions. One structure was a suction cell, and the other was a main frame. The suction cell included the ISFET glucose sensor, a dilution mechanism, and a sucking interface to human skin. The main frame contained a dilution solution reservoir, a liquid waste reservoir, a fluid pump, a vacuum pump, a micro processor, batteries, and a user interface. The system is self-contained for portable usage during up to 6 hrs monitoring. This system may be the first blood glucose monitoring equipment which does not use blood sampling.

Original languageEnglish
Pages (from-to)1017-1022
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number4
Publication statusPublished - 1995 Apr


ASJC Scopus subject areas

  • Medicine(all)

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