A novel carbon skeletal trichothecane, tenuipesine A, isolated from an entomopathogenic fungus, Paecilomyces tenuipes

Haruhisa Kikuchi, Yasuhiro Miyagawa, Koji Nakamura, Yuko Sahashi, Satoshi Inatomi, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

(Chemical equation presented) Tenuipesine A (1), a novel trichothecane with an unprecedented carbon-migrated skeleton that embodies of a cyclopropane ring, was isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), a popular entomopathogenic fungi employed in folk medicine and health foods in China, Korea, and Japan. The structure was determined on the basis of two-dimensional NMR data. Its stereochemistry was elucidated by spectroscopic data and the chemical transformation of the coexisting trichothecene, 4β-acetoxy-12,13-epoxytrichothec-9-ene-3α,15-diol (2).

Original languageEnglish
Pages (from-to)4531-4533
Number of pages3
JournalOrganic Letters
Volume6
Issue number24
DOIs
Publication statusPublished - 2004 Nov 25
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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