A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma

Fumihiko Urano, Akihiro Umezawa, Wei Hong, Haruhito Kikuchi, Jun Ichi Hata

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume219
Issue number2
DOIs
Publication statusPublished - 1996 Feb 15

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Ewing's Sarcoma
Adenoviridae
Tumors
Carrier Proteins
Genes
Primitive Neuroectodermal Tumors
Neoplasms
Genetic Translocation
Tumor Biomarkers
Matrix Metalloproteinases
Transcriptional Activation
Cause of Death
Bone
Tissue
Phenotype
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. / Urano, Fumihiko; Umezawa, Akihiro; Hong, Wei; Kikuchi, Haruhito; Hata, Jun Ichi.

In: Biochemical and Biophysical Research Communications, Vol. 219, No. 2, 15.02.1996, p. 608-612.

Research output: Contribution to journalArticle

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