A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells

Katsuhiko Tabuchi, Shingo Yoshikawa, Yoshihiro Yuasa, Kazunobu Sawamoto, Hideyuki Okano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have isolated a novel Drosophila paired-like homeobox gene, DPHD-1. The homeodomain of DPHD-1 showed 85% amino-acid identity with that of the C. elegans Unc-4 protein. Whole-mount in situ hybridization of embryos and third-instar larvae revealed that the DPHD-1 mRNA is specifically localized in subsets of postmitotic neurons in the central nervous system (CNS) and in the developing epidermis with a segmentally repeated pattern. Double staining with a posterior compartment marker, an anti-Engrailed antibody, showed that DPHD-1 expressing neurons in the CNS were present in the posterior compartment, whereas DPHD-1 expression in the epidermis was restricted to the anterior compartment in each segment. This temporal and spatial expression pattern suggests that DPHD-1 may play a role in determining the distinct cell types in each segment.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalNeuroscience Letters
Volume257
Issue number1
DOIs
Publication statusPublished - 1998 Nov 20
Externally publishedYes

Fingerprint

Homeobox Genes
Caenorhabditis elegans
Epidermis
Drosophila
Central Nervous System
Neurons
In Situ Hybridization
Larva
Anti-Idiotypic Antibodies
Embryonic Structures
Staining and Labeling
Amino Acids
Messenger RNA
C elegans unc-4 protein

Keywords

  • Central nervous system
  • Compartment
  • DPHD-1
  • Drosophila
  • Epidermis
  • Paired-like homeodomain
  • Segmentally repeated pattern
  • unc-4

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells. / Tabuchi, Katsuhiko; Yoshikawa, Shingo; Yuasa, Yoshihiro; Sawamoto, Kazunobu; Okano, Hideyuki.

In: Neuroscience Letters, Vol. 257, No. 1, 20.11.1998, p. 49-52.

Research output: Contribution to journalArticle

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