A novel drug therapy for recurrent laryngeal nerve injury using T-588

Yuko Mori, Akihiro Shiotani, Koichiro Saito, Koji Araki, Ken Ikeda, Masaya Nakagawa, Kazuhiko Watabe, Kaoru Ogawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

OBJECTIVES/HYPOTHESIS: We have previously shown that gene therapy using Insulin-like growth factor (IGF)-I, glial cell line-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF), or a combination of these trophic factors, is a treatment option for recurrent laryngeal nerve (RLN) palsy. However, there remain some difficulties preventing this option from becoming a common clinical therapy for RLN injury. Thus, we need to develop novel treatment option that overcomes the problems of gene therapy.R(-)-1- (benzothiophen-5-yl)-2-[2-N,N-diethylamino]ethoxy]ethanol hydrochloride (T-588), a synthetic compound, is known to have neuroprotective effects on neural cells. In the present study, the possibility of new drug treatments using T-588 for RLN injury was assessed using rat models. STUDY DESIGN: Animal study. METHODS: Animals were administered T-588 for 4 weeks. The neuroprotective effects of T-588 administration after vagal nerve avulsion and neurofunctional recovery after recurrent laryngeal nerve crush were studied using motoneuron cell counting, evaluation of choline acetyltransferase immunoreactivity, the electrophysiologic examination, and the re-mobilization of the vocal fold. RESULTS: T-588 administration successfully prevented motoneuron loss and ameliorated the choline acetyltransferase immunoreactivity in the ipsilateral nucleus ambiguus after vagal nerve avulsion. Significant improvements of motor nerve conduction velocity of the RLN and vocal fold movement were observed in the treatment group when compared to controls. CONCLUSION: These results indicate that oral administration of T-588 might be a promising therapeutic option in treating peripheral nerve injury.

Original languageEnglish
Pages (from-to)1313-1318
Number of pages6
JournalLaryngoscope
Volume117
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

Keywords

  • Avulsion
  • Crush
  • Laryngeal paralysis
  • Motoneuron
  • Nucleus ambiguus
  • T-588

ASJC Scopus subject areas

  • Otorhinolaryngology

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