A novel endoscopic hand-suturing technique for defect closure after colorectal endoscopic submucosal dissection: A pilot study

Seiichiro Abe, Yutaka Saito, Yusaku Tanaka, Mai Ego, Fumito Yanagisawa, Kazumasa Kawashima, Hiroyuki Takamaru, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Osamu Goto, Naohisa Yahagi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background This study aimed to demonstrate the feasibility of endoscopic hand-suturing (EHS) and attainability of sustained closure after colorectal endoscopic submucosal dissection (ESD). Methods EHS was defined as uninterrupted endoscopic suturing of the mucosal defect after colorectal ESD using an absorbable barbed suture and a through-the-scope needle holder. Following individual EHS training using an ex vivo porcine colonic model, two experienced endoscopists performed EHS. Repeat colonoscopy was performed on the third or fourth day after ESD to examine the EHS site. The primary end point was the complete EHS closure rate, and secondary end points were sustained closure and post-ESD bleeding rates. Results 11 lesions were included. Median size of the mucosal defect was 38 mm (range 25-55 mm) and the lesion characteristics were as follows: Lower rectum/upper rectum/ascending colon/cecum = 3/3/2/3, and 0-IIa/0-Is + IIa/others = 5/4/2. EHS was not attempted in two patients owing to difficulty in colonoscope reinsertion after ESD and intraoperative perforation, respectively. EHS was performed for nine lesions, and the complete EHS closure rate was 73 %. Median procedure time for suturing was 56 minutes (range 30-120 minutes) and median number of stitches was 8 (range 6-12). Sustained closure and post-ESD bleeding rates were 64 % and 9 %, respectively. Conclusions EHS achieved complete and sustained closure in the colorectum. However, EHS is not currently clinically applicable given the long procedure time. Further modifications of the technique and devices are desirable.

Original languageEnglish
Pages (from-to)780-785
Number of pages6
JournalEndoscopy
Volume52
Issue number9
DOIs
Publication statusPublished - 2020 Sep 1

ASJC Scopus subject areas

  • Gastroenterology

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