A novel gene delivery system using EGF receptor-mediated endocytosis

Jiabing Chen, Shinobu Gamou, Atsushi Takayanagi, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalFEBS Letters
Volume338
Issue number2
DOIs
Publication statusPublished - 1994 Jan 31

Keywords

  • EGF receptor
  • Endocytosis
  • Gene therapy
  • Monoclonal antibody

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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